Featured Research

from universities, journals, and other organizations

Stressed-out Skin Loses Its Antimicrobial Defense Mechanism

Date:
November 19, 2007
Source:
Journal of Clinical Investigation
Summary:
It is well known that being stressed increases our susceptibility to infections by impairing the function of our immune system, but the molecular links between stress and diminished immune function have not been determined. A new study in mice has provided insight into this issue by showing that psychological stress increased production of glucocorticoids and that this decreased the expression of antimicrobial peptides in the skin, making the mice more susceptible to skin infections.

It is well known that being stressed increases our susceptibility to infections by impairing the function of our immune system, but the molecular links between stress and diminished immune function have not been determined.

However, Peter Elias and colleagues at UCSF, have now characterized a mechanistic link in mice between psychological stress and increased susceptibility to skin infections.

Mice subjected to conditions of psychological stress were found to be more susceptible to group A Streptococcus pyogenes skin infections than mice housed under normal conditions.

This was associated with decreased expression of antimicrobial peptides by the epidermis of the skin. Further analysis revealed that psychological stress induced the increased production of glucocorticoids and that this inhibited the synthesis of fats in the epidermis of the skin and decreased the secretion of vesicles that contain antimicrobial peptides.

As indicated by the authors and Andrzej Slominski from the University of Tennessee, Memphis, in an accompanying commentary, these data lead to the suggestion that the immune function of the skin might be improved in individuals who are stressed by inhibiting the action of glucocorticoids.

Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice, Journal of Clinical Investigation, November 1, 2007


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Stressed-out Skin Loses Its Antimicrobial Defense Mechanism." ScienceDaily. ScienceDaily, 19 November 2007. <www.sciencedaily.com/releases/2007/11/071101193415.htm>.
Journal of Clinical Investigation. (2007, November 19). Stressed-out Skin Loses Its Antimicrobial Defense Mechanism. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2007/11/071101193415.htm
Journal of Clinical Investigation. "Stressed-out Skin Loses Its Antimicrobial Defense Mechanism." ScienceDaily. www.sciencedaily.com/releases/2007/11/071101193415.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins