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Sex, Sugar And Metabolic Disease

Date:
November 12, 2007
Source:
Journal of Clinical Investigation
Summary:
Overweight children and adults have low blood levels of the protein SHGB, which transports sex steroids and regulates their tissue entry. Low levels of SHGB are a marker of the metabolic syndrome, a medical disorder that increases an individual's risk of developing type 2 diabetes and heart disease. New research in mice and in vitro using human cells provides an explanation as to why low SHGB levels are a good marker of the metabolic syndrome.
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Overweight children and adults have low levels in their blood of a protein known as SHGB, which transports sex steroids and regulates their entry into tissues.

Low levels of SHGB are a marker of the metabolic syndrome, a combination of medical disorders that increase an individual's risk of developing type 2 diabetes and heart disease.

An explanation as to why low levels of SHGB are such a good marker of the metabolic syndrome are now provided by Geoffrey Hammond and colleagues at the University of British Columbia, Vancouver.

In the study, exposure to glucose and fructose (monomeric sugar building blocks of carbohydrates) reduced the production of SHGB in vitro by a human liver cell line and in vivo by the liver of mice engineered to express human SHGB.

Decreased production of SHGB was mediated by decreased expression of a protein that stimulates the gene that makes SHGB (HNF-4-alpha) and was associated with increased amounts of the fat palmitate in the liver cells. Importantly, glucose- and fructose-induced decreases in SHGB production were prevented by inhibiting palmitate generation.

These data provide a mechanistic link between excess sugar and carbohydrate consumption and decreased levels of SHGB, indicating the reason it is a good marker of the metabolic syndrome.

Journal article:Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone--binding globulin gene, Journal of Clinical Investigation, November 8, 2007.


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Journal of Clinical Investigation. "Sex, Sugar And Metabolic Disease." ScienceDaily. ScienceDaily, 12 November 2007. <www.sciencedaily.com/releases/2007/11/071108171604.htm>.
Journal of Clinical Investigation. (2007, November 12). Sex, Sugar And Metabolic Disease. ScienceDaily. Retrieved August 30, 2015 from www.sciencedaily.com/releases/2007/11/071108171604.htm
Journal of Clinical Investigation. "Sex, Sugar And Metabolic Disease." ScienceDaily. www.sciencedaily.com/releases/2007/11/071108171604.htm (accessed August 30, 2015).

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