Featured Research

from universities, journals, and other organizations

Biomarkers For Alzheimer's Disease Can Be Trusted In Clinical Trials

Date:
November 19, 2007
Source:
IOS Press
Summary:
The best-established biomarkers for Alzheimer's disease have a low natural variation over two years. The results speak for the inclusion of these biomarkers in clinical trials of novel drugs against Alzheimer's disease.

The best-established biomarkers for Alzheimer's disease have a low natural variation over two years. The results speak for the inclusion of these biomarkers in clinical trials of novel drugs against Alzheimer's disease.

Related Articles


"We show that the best-established diagnostic biomarkers for Alzheimer's disease stay at basically the same level during two years in patients with early Alzheimer's disease. This means that the biomarkers could be useful for detecting even minor biochemical changes induced by treatment in the clinical trials of novel drugs against Alzheimer's," says Henrik Zetterberg, Associate Professor at the Sahlgrenska Academy.

Dr Zetterberg and colleagues analyzed cerebrospinal fluid from more than 80 patients with mild cognitive impairment. Some of these patients developed full-blown Alzheimer's disease. The measured levels of the tau and amyloid-b proteins were compared in samples drawn from the same patients two years apart.

"If a novel drug candidate actually stops or slows down the neurodegenerative disease process in Alzheimer's disease, we should expect a normalized tau concentration in cerebrospinal fluid in patients on active treatment. Such a change should be readily detectable also in a small and inexpensive pilot study, given the low intra-individual variation in biomarker levels over time that was detected in our study," Dr Zetterberg says.

Alzheimer's disease is an age-related brain-damaging disorder that results in progressive cognitive impairment and death. Three decades of progress have resulted in a profound understanding of the molecular mechanisms underlying the disease. In the past 10 years, this knowledge has translated into a range of targets for therapy, the most promising of which is amyloid-b.

The results are presented by researchers at the Sahlgrenska Academy at Göteborg University, Sweden, in the November 2007 issue of the Journal of Alzheimer's Disease,12:3 (November 2007).

Article title: Intra-Individual Stability of CSF Biomarkers for Alzheimer's Disease over Two Years

Authors: Henrik Zetterberg, Mona Pedersen, Karin Lind, Maria Svensson, Sindre Rolstad, Carl Eckerström, Steinar Syversen, Ulla-Britt Mattsson, Chrisina Ysander, Niklas Mattsson, Arto Nordlund, Hugo Vanderstichele, Eugeen Vanmechelen, Michael Jonsson, Åke Edman, kaj Blennow and Anders Wallin


Story Source:

The above story is based on materials provided by IOS Press. Note: Materials may be edited for content and length.


Cite This Page:

IOS Press. "Biomarkers For Alzheimer's Disease Can Be Trusted In Clinical Trials." ScienceDaily. ScienceDaily, 19 November 2007. <www.sciencedaily.com/releases/2007/11/071115093129.htm>.
IOS Press. (2007, November 19). Biomarkers For Alzheimer's Disease Can Be Trusted In Clinical Trials. ScienceDaily. Retrieved April 25, 2015 from www.sciencedaily.com/releases/2007/11/071115093129.htm
IOS Press. "Biomarkers For Alzheimer's Disease Can Be Trusted In Clinical Trials." ScienceDaily. www.sciencedaily.com/releases/2007/11/071115093129.htm (accessed April 25, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, April 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Judge OKs 65-Year Deal Over NFL Concussions

Judge OKs 65-Year Deal Over NFL Concussions

AP (Apr. 23, 2015) — A judge has approved a potential $1 billion plan to resolve thousands of NFL concussion lawsuits filed by retired players. The NFL expects 6,000 of nearly 20,000 retired players to suffer from Alzheimer&apos;s disease or moderate dementia someday.(April 23) Video provided by AP
Powered by NewsLook.com
Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Newsy (Apr. 21, 2015) — The use of complex tools has often been seen as a defining characteristic of humanity, but that notion is now in question. Video provided by Newsy
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) — Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) — Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins