Featured Research

from universities, journals, and other organizations

Drugs May Not Delay Onset Of Dementia

Date:
November 27, 2007
Source:
Public Library of Science
Summary:
Researchers have examined the evidence in favor of giving people considered to be close to developing dementia the drugs that are most commonly used to treat the condition itself. They have concluded that these drugs (cholinesterase inhibitors) do not seem to delay the appearance of Alzheimer's disease or other forms of dementia.

Researchers have examined the evidence in favour of giving people considered to be close to developing dementia the drugs that are most commonly used to treat the condition itself. They have concluded that these drugs (cholinesterase inhibitors) do not seem to delay the appearance of Alzheimer disease or other forms of dementia.

Related Articles


Three cholinesterase inhibitors -- donepezil, rivastigmine and galantamine -- are currently approved for use in mild-to-moderate Alzheimer disease. Some experts are not convinced that they are effective, but other experts and patient support groups have called for the drugs to be given to people with "mild cognitive impairment (MCI)" -- the term that is used to describe the condition where people have memory problems that are more severe than those normally seen in others of their age, but otherwise have no symptoms of dementia. It is believed that people with MCI are at high risk of developing Alzheimer disease.

Dr Raschetti and colleagues at Italy's National Centre for Epidemiology, Surveillance and Health Promotion in Rome conducted a systematic review of the data from clinical trials that had addressed the use of cholinesterase inhibitors with MCI patients. In none of the six trials that they examined did the use of the drugs significantly reduce the rate of progression from MCI to dementia.

One problem that came to light during their review was that there is no generally accepted precise definition for MCI. There was therefore some variation between the trials in the mental state of the people given the drugs. Dr Raschetti and his team have called for more clinical trials to be done, but using a single agreed definition of mild cognitive impairment. Until such trials have found a benefit from using cholinesterase inhibitors in this way, there seems to be no justification for doctors to do so in clinical practice.

Journal citation: Raschetti R, Albanese E, Vanacore N, Maggini M (2007) Cholinesterase inhibitors in mild cognitive impairment: A systematic review of randomised trials. PLoS Med 4(11): e338.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Drugs May Not Delay Onset Of Dementia." ScienceDaily. ScienceDaily, 27 November 2007. <www.sciencedaily.com/releases/2007/11/071126201348.htm>.
Public Library of Science. (2007, November 27). Drugs May Not Delay Onset Of Dementia. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2007/11/071126201348.htm
Public Library of Science. "Drugs May Not Delay Onset Of Dementia." ScienceDaily. www.sciencedaily.com/releases/2007/11/071126201348.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins