Featured Research

from universities, journals, and other organizations

Health-related Disorders Could Originate At Conception, Vitamin Levels Critical

Date:
December 4, 2007
Source:
University of Nottingham
Summary:
Adult health-related disorders, particularly in males, could originate from the events that take place at the point of our conception. Experts say mothers-to-be should make sure they are getting the right amount of vitamin B12 and folate before they even attempt to start a family.

Research by scientists at The University of Nottingham suggests adult health-related disorders, particularly in males, could originate from the events that take place at the point of our conception.

Experts in the Schools of Biosciences and Human Development say mothers-to-be should make sure they are getting the right amount of Vitamin B12 and Folate before they even attempt to start a family.

It is well known that B vitamins are essential for healthy fetal development. Now, for the first time, scientists are reporting that modest reductions can lead to subtle modifications to the DNA.

Researchers have shown that the adult offspring of sheep deprived of B vitamins prior to conception were fatter, showed insulin resistance and had higher blood pressure than animals whose mothers ate a normal diet. This was particularly marked in the adult male offspring.

Working in close collaboration with scientists from the Rowett Institute and SAC in Aberdeen, Dr Kevin Sinclair and colleagues at The University of Nottingham have shown that male offspring of B-deprived mothers were 25 per cent fatter and had significantly higher blood pressure than offspring of sheep given a healthy diet.

Dr Sinclair said: “There is no effect on fertility, or birth weight and young offspring appear quite normal. However, sweeping changes to our DNA take place during conception and we now realise that this period is particularly vulnerable to environmental influences that can affect development and lead to chemical modifications that can make permanent alterations to gene expression.

“If maternal diet is not properly balanced it can upset these processes during conception — it is a vulnerable period in mammalian development.”

The researchers are interested in B Vitamins as they are involved in specific pathways which can influence chemical changes to DNA at the time of conception. These vitamins are found in natural foods such as red meat and green, leafy vegetables. As yet they don’t understand why males are particularly affected by Vitamin B deficiencies.

The study received 556,000 in funding from the National Institute of Child Health and Human Development (USA) and their findings have been published in the journal PNAS (Proceedings of the National Academy of Sciences).


Story Source:

The above story is based on materials provided by University of Nottingham. Note: Materials may be edited for content and length.


Cite This Page:

University of Nottingham. "Health-related Disorders Could Originate At Conception, Vitamin Levels Critical." ScienceDaily. ScienceDaily, 4 December 2007. <www.sciencedaily.com/releases/2007/11/071130222424.htm>.
University of Nottingham. (2007, December 4). Health-related Disorders Could Originate At Conception, Vitamin Levels Critical. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2007/11/071130222424.htm
University of Nottingham. "Health-related Disorders Could Originate At Conception, Vitamin Levels Critical." ScienceDaily. www.sciencedaily.com/releases/2007/11/071130222424.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins