Featured Research

from universities, journals, and other organizations

Health-related Disorders Could Originate At Conception, Vitamin Levels Critical

Date:
December 4, 2007
Source:
University of Nottingham
Summary:
Adult health-related disorders, particularly in males, could originate from the events that take place at the point of our conception. Experts say mothers-to-be should make sure they are getting the right amount of vitamin B12 and folate before they even attempt to start a family.

Research by scientists at The University of Nottingham suggests adult health-related disorders, particularly in males, could originate from the events that take place at the point of our conception.

Related Articles


Experts in the Schools of Biosciences and Human Development say mothers-to-be should make sure they are getting the right amount of Vitamin B12 and Folate before they even attempt to start a family.

It is well known that B vitamins are essential for healthy fetal development. Now, for the first time, scientists are reporting that modest reductions can lead to subtle modifications to the DNA.

Researchers have shown that the adult offspring of sheep deprived of B vitamins prior to conception were fatter, showed insulin resistance and had higher blood pressure than animals whose mothers ate a normal diet. This was particularly marked in the adult male offspring.

Working in close collaboration with scientists from the Rowett Institute and SAC in Aberdeen, Dr Kevin Sinclair and colleagues at The University of Nottingham have shown that male offspring of B-deprived mothers were 25 per cent fatter and had significantly higher blood pressure than offspring of sheep given a healthy diet.

Dr Sinclair said: “There is no effect on fertility, or birth weight and young offspring appear quite normal. However, sweeping changes to our DNA take place during conception and we now realise that this period is particularly vulnerable to environmental influences that can affect development and lead to chemical modifications that can make permanent alterations to gene expression.

“If maternal diet is not properly balanced it can upset these processes during conception — it is a vulnerable period in mammalian development.”

The researchers are interested in B Vitamins as they are involved in specific pathways which can influence chemical changes to DNA at the time of conception. These vitamins are found in natural foods such as red meat and green, leafy vegetables. As yet they don’t understand why males are particularly affected by Vitamin B deficiencies.

The study received 556,000 in funding from the National Institute of Child Health and Human Development (USA) and their findings have been published in the journal PNAS (Proceedings of the National Academy of Sciences).


Story Source:

The above story is based on materials provided by University of Nottingham. Note: Materials may be edited for content and length.


Cite This Page:

University of Nottingham. "Health-related Disorders Could Originate At Conception, Vitamin Levels Critical." ScienceDaily. ScienceDaily, 4 December 2007. <www.sciencedaily.com/releases/2007/11/071130222424.htm>.
University of Nottingham. (2007, December 4). Health-related Disorders Could Originate At Conception, Vitamin Levels Critical. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2007/11/071130222424.htm
University of Nottingham. "Health-related Disorders Could Originate At Conception, Vitamin Levels Critical." ScienceDaily. www.sciencedaily.com/releases/2007/11/071130222424.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins