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Replacing The Cells Lost In Parkinson Disease

Date:
December 5, 2007
Source:
Journal of Clinical Investigation
Summary:
Parkinson disease is caused by the progressive degeneration of dopamine brain cells. Replacing these cells is considered a promising therapeutic strategy. Although DA cell--replacement therapy by transplantation of human fetal mesencephalic tissue has shown promise, limited tissue availability means other sources of these cells are needed. A recent study has described one new source for DA cells that provided marked benefit when transplanted into mice with a PD-like disease.
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Parkinson disease (PD) is caused by the progressive degeneration of brain cells known as dopamine (DA) cells.

Replacing these cells is considered a promising therapeutic strategy. Although DA cell--replacement therapy by transplantation of human fetal mesencephalic tissue has shown promise in clinical trials, limited tissue availability means that other sources of these cells are needed.

Now, Ernest Arenas and colleagues at the Karolinska Institue, Sweden, have identified a new source for DA cells that provided marked benefit when transplanted into mice with a PD-like disease.

In the study, DA cells were derived from ventral midbrain (VM) neural stem cells/progenitors by culturing them in the presence of a number of factors -- FGF2, sonic hedgehog, and FGF8 -- and engineering them to express Wnt5a.

This protocol generated 10-fold more DA cells than did conventional FGF2 treatment. Further analysis revealed that these cells initiated substantial cellular and functional recovery when transplanted into mice with PD-like disease.

Importantly, the mice did not develop tumors, a potential risk that has precluded the clinical development of embryonic stem cells as a source of DA cells. These data led the authors to suggest that Wnt5a-treated neural stem cells might be an efficient and safe source of DA cells for the treatment of individuals with PD.

The article Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice is published in the December 3 issue of the Journal of Clinical Investigation.


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The above post is reprinted from materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


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Journal of Clinical Investigation. "Replacing The Cells Lost In Parkinson Disease." ScienceDaily. ScienceDaily, 5 December 2007. <www.sciencedaily.com/releases/2007/12/071203190623.htm>.
Journal of Clinical Investigation. (2007, December 5). Replacing The Cells Lost In Parkinson Disease. ScienceDaily. Retrieved July 1, 2015 from www.sciencedaily.com/releases/2007/12/071203190623.htm
Journal of Clinical Investigation. "Replacing The Cells Lost In Parkinson Disease." ScienceDaily. www.sciencedaily.com/releases/2007/12/071203190623.htm (accessed July 1, 2015).

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