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Brain Overgrowth In One-year-olds Linked To Development Of Autism, Study Says

Date:
December 10, 2007
Source:
American College of Neuropsychopharmacology
Summary:
Brain overgrowth in the latter part of an infant's first year may contribute to the onset of autistic characteristics, according to research. These findings support concurrent research which has found brain overgrowth in autistic children as young as 2 years old.
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 Brain overgrowth in the latter part of an infant's first year may contribute to the onset of autistic characteristics, according to new research. These findings support concurrent research which has found brain overgrowth in autistic children as young as two years old.

Lead researcher Joseph Piven, M.D., Director of the Neurodevelopmental Disorders Research Center at the University of North Carolina, Chapel Hill and an ACNP member, says that behavioral studies of infants at high risk for autism suggest that the onset of most behavioral symptoms which define the disorder, such as problems with and social interaction, also occur at about age one. "One reason these findings are important is because early post-natal onset raises the possibility that there may be a window for early treatment and prevention that could be identified by future studies," Piven says.

Autism, a pervasive developmental disorder characterized by severe deficits in social interaction and communication, is associated with a restricted range of activities and interests, as well as stereotyped repetitive behaviors such as lining up toys in a certain way or requiring basic routines.

In normal brain development, neuronal connections are eliminated through a process called "pruning." This process refines normal brain connections and increases the efficiency of remaining connections in the brain. Piven says one possibility is that there is less pruning in children with autism and therefore, their brains become larger than in children without autism.

Piven cautions that while the study seems to suggest a link between brain overgrowth and autism, there are many variants of autism among children, so the ways in which autistic children develop and are affected by brain growth can vary greatly.

Piven says he will continue to study brain development in autism through a study which is part of the new Autism Centers of Excellence funded by the National Institutes of Health. This study will examine more than 500 infant siblings of autistic individuals with magnetic resonance imaging at the University of North Carolina, Children's Hospital of Philadelphia, Washington University of St. Louis and the University of Washington in Seattle. Siblings of autistic children will be examined at 6, 12 and 24 months. Some of them are expected to develop autistic behavior during the course of the study.

Previous studies of both brain development on MRI and behavioral development have not been conducted in children this young, at risk for an autism spectrum disorder. This study will provide important new information on brain changes in infancy that are associated with the development of autistic symptoms.

This research was presented December 8, 2007 at the American College of Neuropsychopharmacology (ACNP) annual meeting. 


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The above post is reprinted from materials provided by American College of Neuropsychopharmacology. Note: Materials may be edited for content and length.


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American College of Neuropsychopharmacology. "Brain Overgrowth In One-year-olds Linked To Development Of Autism, Study Says." ScienceDaily. ScienceDaily, 10 December 2007. <www.sciencedaily.com/releases/2007/12/071208092451.htm>.
American College of Neuropsychopharmacology. (2007, December 10). Brain Overgrowth In One-year-olds Linked To Development Of Autism, Study Says. ScienceDaily. Retrieved July 29, 2015 from www.sciencedaily.com/releases/2007/12/071208092451.htm
American College of Neuropsychopharmacology. "Brain Overgrowth In One-year-olds Linked To Development Of Autism, Study Says." ScienceDaily. www.sciencedaily.com/releases/2007/12/071208092451.htm (accessed July 29, 2015).

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