Featured Research

from universities, journals, and other organizations

Chemotherapy And Tamoxifen Reduce Risk Of Second Breast Cancer, Study Finds

Date:
December 27, 2007
Source:
Journal of the National Cancer Institute
Summary:
Among breast cancer patients, both chemotherapy and tamoxifen independently reduced the risk of developing a second cancer in the other breast, according to a study published online Dec. 25 in the Journal of the National Cancer Institute. The risk reduction persisted for at least 10 and 5 years, respectively.

Among breast cancer patients, both chemotherapy and tamoxifen independently reduced the risk of developing a second cancer in the other breast, according to a study published online December 25 in the Journal of the National Cancer Institute. The risk reduction persisted for at least 10 and 5 years, respectively.

For breast cancer patients the risk of developing cancer in the other breast is two to six times greater than the breast cancer risk of the general public. Studies have shown that taking tamoxifen for five years reduces the risk of cancer in the opposite breast among women who have estrogen receptor-positive breast cancer, but the studies did not clarify how long the protective effect lasts.

Lisbeth Bertelsen, M.D., of the Danish Cancer Society in Copenhagen and colleagues investigated the relationship between tamoxifen and chemotherapy--either alone or in combination--and the risk of cancer in the opposite breast among American and Danish women who were first diagnosed with breast cancer before age 55. The study included 1,158 women who developed cancer in one breast and an additional 634 who initially had cancer in one breast then developed a second cancer in the other breast.

The chemotherapy treatment was associated with a 43 percent reduced risk for developing cancer in the opposite breast, compared with no chemotherapy. This risk reduction lasted up to 10 years after the initial cancer diagnosis and was stronger among women who entered menopause within a year of their diagnosis. Tamoxifen use was associated with a 34 percent reduced risk of a second breast cancer, compared with no tamoxifen use, and this reduction continued for five years after diagnosis.

"Ovarian suppression caused by chemotherapy may have a role in the association, possibly in combination with a cytotoxic effect on [breast tumor cells]," the authors write.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Chemotherapy And Tamoxifen Reduce Risk Of Second Breast Cancer, Study Finds." ScienceDaily. ScienceDaily, 27 December 2007. <www.sciencedaily.com/releases/2007/12/071226003841.htm>.
Journal of the National Cancer Institute. (2007, December 27). Chemotherapy And Tamoxifen Reduce Risk Of Second Breast Cancer, Study Finds. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2007/12/071226003841.htm
Journal of the National Cancer Institute. "Chemotherapy And Tamoxifen Reduce Risk Of Second Breast Cancer, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2007/12/071226003841.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins