Featured Research

from universities, journals, and other organizations

Ashkenazi Ovarian Cancer Patients With BRCA Mutations Live Longer Than Those With Normal Gene

Date:
January 2, 2008
Source:
American Society of Clinical Oncology
Summary:
Israeli investigators have found that Ashkenazi Jewish women with ovarian cancer who have mutations in the BRCA1 or BRCA2 genes lived significantly longer than Ashkenazi Jewish ovarian cancer patients without these mutations. After up to nine years of follow-up, BRCA1/2 mutation carriers were 28 percent less likely to die from the disease, even though women with the BRCA mutations are significantly more likely to develop ovarian and breast cancers.

Israeli investigators have found that Ashkenazi Jewish women with ovarian cancer who have mutations in the BRCA1 or BRCA2 genes lived significantly longer than Ashkenazi Jewish ovarian cancer patients without these mutations. After up to nine years of follow-up, BRCA1/2 mutation carriers were 28 percent less likely to die from the disease, even though women with the BRCA mutations are significantly more likely to develop ovarian and breast cancers.

Related Articles


"These findings are encouraging news for BRCA mutation carriers," said Siegal Sadetzki, MD, MPH, head of the Cancer & Radiation Epidemiology Unit at the Gertner Institute, Chaim Sheba Medical Center in Tel Hashomer, Israel and the study's senior author. "It's possible that patients with these mutations respond better to chemotherapy -- hopefully, once we learn more about the mechanisms of this response, tailoring individual treatment will further improve survival."

Normal BRCA1/2 genes control cell growth. Mutations in these genes, which are more common among Ashkenazi Jewish women (Jewish women of Eastern European descent) than in the general population, increase the risk of breast and ovarian cancers.

In one of the largest studies of this topic to date, the researchers from the National Israeli Study of Ovarian Cancer compared five-year survival between 213 Ashkenazi ovarian cancer patients with BRCA1/2 mutations ("carriers") and 392 Ashkenazi ovarian cancer patients without the mutations ("non-carriers").

After five years, 46 percent of the carriers were still alive, compared with 34.4 percent of the non-carriers. Median survival was 53.7 months for carriers and 37.9 months for non-carriers. The differences in survival were most pronounced for women diagnosed with more advanced disease (stage III or IV), with five-year survival rates of 38.1 percent for carriers and 24.5 percent for non-carriers. These findings persisted after controlling for other factors that influence ovarian cancer survival, such as patient age and some biological features of the tumor.

The researchers also analyzed ovarian cancer survival according to whether women had a BRCA1 or a BRCA2 mutation. Women with BRCA1 mutations lived a median of 45.1 months, and women with BRCA2 mutations lived a median of 52.5 months.

The study is being published January 1 in the Journal of Clinical Oncology.

Journal article: "Effect of BRCA1/2 Mutations on Long-Term Survival of Invasive Ovarian Cancer." Angela Chetrit, et al, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.


Story Source:

The above story is based on materials provided by American Society of Clinical Oncology. Note: Materials may be edited for content and length.


Cite This Page:

American Society of Clinical Oncology. "Ashkenazi Ovarian Cancer Patients With BRCA Mutations Live Longer Than Those With Normal Gene." ScienceDaily. ScienceDaily, 2 January 2008. <www.sciencedaily.com/releases/2008/01/080101184644.htm>.
American Society of Clinical Oncology. (2008, January 2). Ashkenazi Ovarian Cancer Patients With BRCA Mutations Live Longer Than Those With Normal Gene. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2008/01/080101184644.htm
American Society of Clinical Oncology. "Ashkenazi Ovarian Cancer Patients With BRCA Mutations Live Longer Than Those With Normal Gene." ScienceDaily. www.sciencedaily.com/releases/2008/01/080101184644.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins