Featured Research

from universities, journals, and other organizations

Duloxetine Does Not Relieve Painful Physical Symptoms In Depression, According To Current Analysis

Date:
January 22, 2008
Source:
Journal of Psychotherapy and Psychosomatics
Summary:
Duloxetine is marketed as a treatment for both the core emotional symptoms and painful physical complaints that often accompany depression. Based upon the currently available evidence, the marketing of duloxetine as an antidepressant with analgesic properties for people with depression does not appear to be adequately supported.

An analysis of the data which are available, published in the European Journal Psychotherapy and Psychosomatics, discloses that the maker’s claims are not warranted.

Duloxetine inhibits both serotonin and norepinephrine reuptake and is marketed as a treatment for both the core emotional symptoms and painful physical complaints that often accompany depression.

Some studies have found that duloxetine is efficacious in treating painful symptoms associated with depression but these findings have been inconsistent. Several narrative review articles have reached positive conclusions about the efficacy of duloxetine as an analgesic in depression but there has been no quantitative systematic review regarding the impact of duloxetine on pain among this population.

A meta-analysis of data pertaining to duloxetine's purported analgesic effects on depressed patients was thus undertaken. Studies were selected through searching Medline and Cochrane Trial databases as well as examining Lilly's public clinical trial database. A random effects model was used. Across five trials, the results indicate a very small (d = 0.115) and statistically nonsignificant (p = 0.057) analgesic effect for duloxetine.

Additionally, some of the relevant data on duloxetine's effects have not been reported fully, making it likely that the obtained results reflect an overestimate of its true impact on painful physical symptoms in depression.

The current analysis is based on a small number of studies; further trials may yield significant results favoring duloxetine. Based upon the currently available evidence, the marketing of duloxetine as an antidepressant with analgesic properties for people with depression does not appear to be adequately supported.


Story Source:

The above story is based on materials provided by Journal of Psychotherapy and Psychosomatics. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Psychotherapy and Psychosomatics. "Duloxetine Does Not Relieve Painful Physical Symptoms In Depression, According To Current Analysis." ScienceDaily. ScienceDaily, 22 January 2008. <www.sciencedaily.com/releases/2008/01/080121120154.htm>.
Journal of Psychotherapy and Psychosomatics. (2008, January 22). Duloxetine Does Not Relieve Painful Physical Symptoms In Depression, According To Current Analysis. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/01/080121120154.htm
Journal of Psychotherapy and Psychosomatics. "Duloxetine Does Not Relieve Painful Physical Symptoms In Depression, According To Current Analysis." ScienceDaily. www.sciencedaily.com/releases/2008/01/080121120154.htm (accessed July 31, 2014).

Share This




More Mind & Brain News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dieting At A Young Age Might Lead To Harmful Health Habits

Dieting At A Young Age Might Lead To Harmful Health Habits

Newsy (July 30, 2014) Researchers say women who diet at a young age are at greater risk of developing harmful health habits, including eating disorders and alcohol abuse. Video provided by Newsy
Powered by NewsLook.com
It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins