Featured Research

from universities, journals, and other organizations

Pathology Reports Acceptable For Determining ER Status In Breast Cancer Trials

Date:
January 30, 2008
Source:
Journal of the National Cancer Institute
Summary:
Pathology reports offer a fairly accurate alternative to repeated testing in a central laboratory for determining estrogen receptor status in large epidemiologic studies of women with breast cancer. When conducting epidemiologic studies of breast cancer patients, researchers often use pathology reports to obtain estrogen receptor status instead of testing them again in a central laboratory, which can be impractical.

Pathology reports offer a fairly accurate alternative to repeated testing in a central laboratory for determining estrogen receptor status in large epidemiologic studies of women with breast cancer.

Related Articles


When conducting epidemiologic studies of breast cancer patients, researchers often use pathology reports to obtain estrogen receptor status instead of testing them again in a central laboratory, which can be impractical.

But it was unknown whether these original pathology reports were accurate or not, and misclassification of estrogen receptor status could have a serious impact on the results of a study.

Laura Collins, M.D., of Beth Israel Deaconess Medical Center in Boston and colleagues assessed the reliability of estrogen receptor results from pathology reports by comparing them with immunohistochemical tests that they had performed by a central laboratory.

The pathology reports and the later tests were the same for 1,615 of the 1,851 samples (87.3 percent). The authors concluded that there was a high rate of agreement between the pathology reports and the central laboratory tests.

"Our findings, therefore, indicate that using [estrogen receptor] assay results from pathology reports is a reasonable alternative to using central laboratory testing to obtain [estrogen receptor] results in large, population-based studies of women with breast cancer," the authors write.

This research was recently published in the Journal of the National Cancer Institute.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Pathology Reports Acceptable For Determining ER Status In Breast Cancer Trials." ScienceDaily. ScienceDaily, 30 January 2008. <www.sciencedaily.com/releases/2008/01/080129200314.htm>.
Journal of the National Cancer Institute. (2008, January 30). Pathology Reports Acceptable For Determining ER Status In Breast Cancer Trials. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2008/01/080129200314.htm
Journal of the National Cancer Institute. "Pathology Reports Acceptable For Determining ER Status In Breast Cancer Trials." ScienceDaily. www.sciencedaily.com/releases/2008/01/080129200314.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins