Featured Research

from universities, journals, and other organizations

Tamoxifen May Help Treat Mania In Patients With Bipolar Disorder

Date:
March 4, 2008
Source:
JAMA and Archives Journals
Summary:
A small, three-week trial of tamoxifen, a drug typically used to treat breast cancer, indicates that it also may decrease symptoms of mania in patients with bipolar disorder, according to a new article.

A small, three-week trial of tamoxifen, a drug typically used to treat breast cancer, indicates that it also may decrease symptoms of mania in patients with bipolar disorder, according to a new report.

Tamoxifen interferes with the effects of the hormone estrogen, which accounts for its effects against breast cancer, according to background information in the article. However, tamoxifen also inhibits the actions of a family of enzymes known as protein kinase C. Abnormal levels of activity by these enzymes have been associated with bipolar disorder and related dysfunctions, such as distractibility, impaired judgments and disorganized thoughts.

Animal studies and human pilot trials have suggested that tamoxifen may be effective in treating mania--an abnormally elevated mood that features impulsive behavior, higher energy and activity levels, and disconnected thoughts--in patients with bipolar disorder. Ayegül Yildiz, M.D., of the Dokuz Eylül University Medical School, Izmir, Turkey, and colleagues conducted a clinical trial with 66 patients age 18 to 60, all of whom were diagnosed with bipolar disorder and were currently in a manic state or a mixed state that included mania. Participants were randomly assigned to take tamoxifen (40 milligrams to 80 milligrams per day) or identical placebo tablets twice daily for up to three weeks. Participants in both groups also were given up to 5 milligrams per day of the sedative lorazepam as needed to control their symptoms.

A total of 50 patients--29 assigned to take tamoxifen and 21 assigned to take placebo--completed the 21-day trial. Patients in the tamoxifen group had significantly lower scores on tests used to measure the severity of mania at the end of the three-week period, while those in the placebo group had scores that slightly increased. Almost half (48 percent) of patients taking tamoxifen responded to the drug--defined as a reduction of at least half in mania scores--compared with 5 percent of those taking placebo, and 28 percent vs. zero achieved cutoff scores for mania remission.

Patients taking tamoxifen also used less lorazepam during the study--an average of 25.2 milligrams compared with 41.8 milligrams for patients in the placebo group. "Moreover, all subjects used less lorazepam as the trial progressed, and the rate of decrease was 2.5 times greater with tamoxifen," the authors write. Both tamoxifen and placebo were well tolerated.

"The findings encourage further clarification of the role of protein kinase C in the pathophysiologic mechanism of bipolar 1 disorder and development of novel anti--protein kinase C agents as potential antimanic or mood-stabilizing agents," the authors conclude.

Journal reference: Arch Gen Psychiatry. 2008;65[3]:255-263.

This study was supported by a research grant from the Stanley Medical Research Institute.

Editorial: Targeted Therapies Represent Future of Bipolar Disorder Treatment

"The role of tamoxifen per se in the treatment of bipolar disorder still remains to be determined, but its anti-estrogen effects are likely to present a safety challenge," writes Mauricio Tohen, M.D., Dr.P.H., of Eli Lilly Corporate Center, Indianapolis, in an accompanying editorial.

"The evidence-based selection of the therapeutic targets that led to this study hopefully will lead to similar approaches by industry, government and academia in the development of new and better treatments for bipolar disorder," Dr. Tohen concludes. "Undoubtedly, this will be an important step to conquer this devastating disorder that affects millions of patients around the globe."

Reference for editorial: Arch Gen Psychiatry. 2008;65[3]:252-253.

Disclosure: Dr. Tohen is a full-time employee and a stockholder of Eli Lilly and Company.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Tamoxifen May Help Treat Mania In Patients With Bipolar Disorder." ScienceDaily. ScienceDaily, 4 March 2008. <www.sciencedaily.com/releases/2008/03/080303190626.htm>.
JAMA and Archives Journals. (2008, March 4). Tamoxifen May Help Treat Mania In Patients With Bipolar Disorder. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/03/080303190626.htm
JAMA and Archives Journals. "Tamoxifen May Help Treat Mania In Patients With Bipolar Disorder." ScienceDaily. www.sciencedaily.com/releases/2008/03/080303190626.htm (accessed July 31, 2014).

Share This




More Mind & Brain News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dieting At A Young Age Might Lead To Harmful Health Habits

Dieting At A Young Age Might Lead To Harmful Health Habits

Newsy (July 30, 2014) — Researchers say women who diet at a young age are at greater risk of developing harmful health habits, including eating disorders and alcohol abuse. Video provided by Newsy
Powered by NewsLook.com
It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) — If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) — Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) — A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins