Featured Research

from universities, journals, and other organizations

Anchoring Protein Variant Associated with Increased Breast Cancer Risk

Date:
March 14, 2008
Source:
Journal of the National Cancer Institute
Summary:
Individuals who carry a rare genetic variant have an increased risk of developing breast cancer over their lifetimes, compared with those who do not have the variant. Few genes have been found to have a large impact on the risk of familial breast cancer, and researchers expect that most breast cancers are influenced by the combined effects of multiple genes, each of which has a small impact on its own. One of those genes may be AKAP9.

Individuals who carry a rare genetic variant have an increased risk of developing breast cancer over their lifetimes, compared with those who do not have the variant.

Related Articles


Few genes have been found to have a large impact on the risk of familial breast cancer, and researchers expect that most breast cancers are influenced by the combined effects of multiple genes, each of which has a small impact on its own. One of those genes may be AKAP9.

To determine whether a rare sequence variant of the AKAP9 gene increases the risk of breast cancer, Barbara Burwinkel, Ph.D., of the German Cancer Research Center in Heidelberg and colleagues compared the frequency of the variant in 9,523 breast cancer patients with its frequency in 13,770 healthy control subjects from a large international collaboration project.

The team found that individuals who carry two copies of the rare variant have a 17 percent increased relative risk of developing breast cancer compared with those who carry two copies of the normal sequence. For those individuals who carry one copy of the rare variant and one copy of the normal sequence, their relative risk increased 10 percent over their lifetime.

"It is also of interest that this variant has previously been found to be associated with colorectal and lung cancer risk," the authors write.

This research was published in the March 11 issue of the Journal of the National Cancer Institute.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Anchoring Protein Variant Associated with Increased Breast Cancer Risk." ScienceDaily. ScienceDaily, 14 March 2008. <www.sciencedaily.com/releases/2008/03/080311165935.htm>.
Journal of the National Cancer Institute. (2008, March 14). Anchoring Protein Variant Associated with Increased Breast Cancer Risk. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2008/03/080311165935.htm
Journal of the National Cancer Institute. "Anchoring Protein Variant Associated with Increased Breast Cancer Risk." ScienceDaily. www.sciencedaily.com/releases/2008/03/080311165935.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins