Featured Research

from universities, journals, and other organizations

Link Between Alzheimer's And Stroke Illuminated

Date:
March 19, 2008
Source:
Columbia University Medical Center
Summary:
Researchers have found a process in the brain that may help explain the link between Alzheimer's and stroke. This finding connects the dots between a peptide called p25 and increased production of amyloid beta. This newly identified p25/cdk5 pathway could explain why the risk of Alzheimer's disease is significantly higher following a stroke.

For years, neuroscientists have known that the risk of Alzheimer’s disease is nearly doubled among people who have had a stroke. Now researchers at Columbia University Medical Center have found a process in the brain that may help explain the link between Alzheimer’s and stroke. Findings are published in the March 13, 2008 issue of Neuron.

After a stroke, it is known that there is an increase in the production of the toxic amyloid beta (Aβ) peptides that are believed to cause Alzheimer’s disease. In this study, results showed that Aβ production rises when there is an increase in production of a peptide called p25, which is known to occur, both in rodent models and in human post-mortem tissue, following a stroke. Columbia researchers and their colleagues identified a pathway, known as p25/cdk5, whereby higher levels of p25 led to enhanced activity of a molecule called cdk5, which in turn led to a rise in the production of Aβ.

When lead author Karen Duff, Ph.D. and her colleagues reduced the activity of cdk5 either using an inhibitor, or by genetic manipulation, they found a decrease in Aβ production in the brain. These results indicate that the p25/cdk5 pathway may be a treatment target for Alzheimer’s disease – in particular, inhibitors of cdk5 are particular candidates for therapeutic development.

“This finding connects the dots between p25 and increased production of amyloid beta, and this p25/cdk5 pathway could explain why the risk of Alzheimer’s disease is significantly higher following a stroke,” said Dr. Duff, professor of pathology (in psychiatry and in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain) at Columbia University Medical Center and the New York State Psychiatric Institute. “However, we still need to verify that this pathway is actually set in motion after a stroke; right now the data is still circumstantial.”

Duff’s laboratory is currently working on experiments to verify this pathway’s involvement using human post-mortem tissue of stroke patients.

The specific pathway investigated was shown to be most active in young mice, as compared to older mice suggesting that p25/cdk5 may not be implicated in late-onset Alzheimer’s disease, the most common form of this neurodegenerative disease.

Facts about Alzheimer’s Disease

Alzheimer’s disease, which affects 4.5 million Americans, is differentiated as either early-onset or late-onset. The early-onset form is rare and tends to affect those between the ages of 30-60. Most cases of early-onset are genetic, caused by a mutation of the APP gene. The late-onset form is much more common – accounts for 90 percent of all cases of Alzheimer’s – and tends to affect those aged 65 and older. With aging baby boomers, the prevalence of late-onset Alzheimer’s is expected to double in the next 25 years as the population ages.


Story Source:

The above story is based on materials provided by Columbia University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Columbia University Medical Center. "Link Between Alzheimer's And Stroke Illuminated." ScienceDaily. ScienceDaily, 19 March 2008. <www.sciencedaily.com/releases/2008/03/080317093908.htm>.
Columbia University Medical Center. (2008, March 19). Link Between Alzheimer's And Stroke Illuminated. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/03/080317093908.htm
Columbia University Medical Center. "Link Between Alzheimer's And Stroke Illuminated." ScienceDaily. www.sciencedaily.com/releases/2008/03/080317093908.htm (accessed July 31, 2014).

Share This




More Mind & Brain News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dieting At A Young Age Might Lead To Harmful Health Habits

Dieting At A Young Age Might Lead To Harmful Health Habits

Newsy (July 30, 2014) Researchers say women who diet at a young age are at greater risk of developing harmful health habits, including eating disorders and alcohol abuse. Video provided by Newsy
Powered by NewsLook.com
It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins