Featured Research

from universities, journals, and other organizations

Hormone That Controls Hunger And Appetite Also Linked To Reduced Fertility

Date:
March 31, 2008
Source:
Yale University
Summary:
Researchers at Yale School of Medicine have found that in-utero exposure to the hormone grhelin, a molecule that controls appetite and hunger and nutrition, can result in decreased fertility and fewer offspring.

Researchers at Yale School of Medicine have found that in-utero exposure to the hormone grhelin, a molecule that controls appetite and hunger and nutrition, can result in decreased fertility and fewer offspring.

Ghrelin, the so-called "hunger hormone," is produced in the stomach and brain, induces food intake, and operates through a brain region that controls cravings for food and other energy sources. Ghrelin decreases the HOXA 10 gene that is involved in developmental programming of the uterus. The HOXA 10 gene determines how the uterus will develop in adulthood.

"When you're obese, ghrelin levels are lower, and based on these preliminary findings, they may result in lower fertility," said lead author on the abstract, Hugh S. Taylor, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences and section chief of Reproductive Endocrinology and Infertility at Yale School of Medicine.

The researchers bred mice designed to be deficient in ghrelin production. These mice had offspring with decreased fertility and that produced smaller litter sizes. These offspring also had lower expression of the HOXA 10 gene, which is important for proper development of the uterus in the embryo. In the adult uterus, it maintains the ability of the uterus to provide an optimal environment for proper development of the embryo.

"Obesity may have an effect on pregnancy in the next generation," said Taylor, adding that the findings underscore the importance of nutrition, energy utilization and appropriate ghrelin levels on normal uterine development. Taylor and his team will next study the effects of lower ghrelin levels on humans.

Results from this research will be presented in an abstract at the 2008 Society for Gynecologic Investigation (SGI) Annual Scientific Meeting held March 26-29 in San Diego, California. Other authors include Amy Tetrault, who will present the abstract at SGI, Sarah Lieber, Marya Shanabrough and Tamas Horvath.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Hormone That Controls Hunger And Appetite Also Linked To Reduced Fertility." ScienceDaily. ScienceDaily, 31 March 2008. <www.sciencedaily.com/releases/2008/03/080331093513.htm>.
Yale University. (2008, March 31). Hormone That Controls Hunger And Appetite Also Linked To Reduced Fertility. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/03/080331093513.htm
Yale University. "Hormone That Controls Hunger And Appetite Also Linked To Reduced Fertility." ScienceDaily. www.sciencedaily.com/releases/2008/03/080331093513.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins