Featured Research

from universities, journals, and other organizations

No Benefit Found From Continuing Neuroleptic Drugs In Alzheimer's Patients, Study Shows

Date:
March 31, 2008
Source:
Public Library of Science
Summary:
Results of a randomized trial show no benefit in cognitive or neuropsychiatric outcomes from continuing neuroleptic drugs in patients with Alzheimer's disease. Almost all older dementia patients will have some neuropsychiatric symptoms. These symptoms can include agitation, aggression, and psychosis. Neuroleptics (sometimes called antipsychotics) are the class of drugs often used to manage or control neuropsychiatric problems, but there have been questions about their safety and appropriateness.

Results of a randomised trial show no benefit in cognitive or neuropsychiatric outcomes from continuing neuroleptic drugs in patients with Alzheimer's disease.

The researchers, led by Clive Ballard from King's College hospital, London, recruited 165 patients from across the UK who were already being treated with neuroleptic drugs. They randomised half of the patients to continue treatment and half to discontinue treatment. At 6 and 12 months the patients that remained in each group were assessed for their cognitive status and neuropsychiatric symptoms.

The researchers found that there were no differences between the two groups in terms of cognitive decline. They also found no overall differences between the two groups in the change in the number of neuropsychiatric symptoms. Patients with severe neuropsychiatric problems at the outset of the trial may have had some benefit from continued neuroleptic therapy, but this difference was not statistically significant.

Almost all older dementia patients will have some neuropsychiatric symptoms. These symptoms can include agitation, aggression, and psychosis. Neuroleptics (sometimes called antipsychotics) are the class of drugs often used to manage or control neuropsychiatric problems, but there have been questions about their safety and appropriateness. Safety concerns, in this group of patients especially, are an increased risk of stroke, parkinsonism, sedation, edema, and chest infections. There may also be a worsening of cognitive decline with prolonged use of neuroleptics.

The findings in the patients studied here do not indicate any benefit of continuing neuroleptic therapies in older patients with dementia. However, the numbers of patients studied in this trial is small. More studies are urgently needed to improve the management of these patients.

Journal reference: Ballard C, Lana MM, Theodoulou M, Douglas S, McShane R, et al. (2008) A randomised, blinded, placebo-controlled trial in dementia patients continuing or stopping neuroleptics (the DART-AD Trial). PLoS Med 5(4): e76.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "No Benefit Found From Continuing Neuroleptic Drugs In Alzheimer's Patients, Study Shows." ScienceDaily. ScienceDaily, 31 March 2008. <www.sciencedaily.com/releases/2008/03/080331223830.htm>.
Public Library of Science. (2008, March 31). No Benefit Found From Continuing Neuroleptic Drugs In Alzheimer's Patients, Study Shows. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2008/03/080331223830.htm
Public Library of Science. "No Benefit Found From Continuing Neuroleptic Drugs In Alzheimer's Patients, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2008/03/080331223830.htm (accessed September 30, 2014).

Share This



More Mind & Brain News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
Your Spouse's Personality May Influence Your Earnings

Your Spouse's Personality May Influence Your Earnings

Newsy (Sep. 26, 2014) Research from Washington University suggest people with conscientious spouses have greater career success. Video provided by Newsy
Powered by NewsLook.com
Can A Blood Test Predict Psychosis Risk?

Can A Blood Test Predict Psychosis Risk?

Newsy (Sep. 26, 2014) Researchers say certain markers in the blood can predict risk of psychosis later in the life. The test can aid in early treatment for the condition. Video provided by Newsy
Powered by NewsLook.com
Harpist Soothes Gorillas, Orangutans With Music

Harpist Soothes Gorillas, Orangutans With Music

AP (Sep. 25, 2014) Teri Tacheny, a harpist, has a loyal following of fans who appreciate her soothing music. Every month, gorillas, orangutans and monkeys amble down to hear her play at the Como Park Zoo in Minnesota. (Sept. 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins