Featured Research

from universities, journals, and other organizations

Diuretics Associated With Bone Loss In Older Men

Date:
April 17, 2008
Source:
JAMA and Archives Journals
Summary:
Older men who take loop diuretics, commonly prescribed drugs for heart failure and hypertension, appear to have increased rates of hip bone loss than men who are not taking this medication, according to a new report.

Older men who take loop diuretics, commonly prescribed drugs for heart failure and hypertension, appear to have increased rates of hip bone loss than men who are not taking this medication, according to a new report.

"Loop diuretics are one of the most commonly prescribed medications among older adults," the authors write as background information in the article. These medications increase the amount of calcium excreted in urine, potentially damaging bones over the long term. In observational studies, use of loop diuretics has been associated with an increased risk of hip and other fractures. "However, there is uncertainty as to whether this increased fracture risk is attributable to negative effects on bone mineral density, fall-related mechanisms (e.g., dizziness and orthostasis [low blood pressure when standing up]), or associated comorbidities [co-occurring illnesses]."

Lionel S. Lim, M.D., M.P.H., of Griffin Hospital, Derby, Conn., and colleagues studied 3,269 men age 65 and older (average age 72.7). At an initial examination between 2000 and 2002 and at a follow-up visit an average of 4.6 years later, the men answered questions about medication use and brought in containers for all medication taken during the past 30 days. Bone mineral density of the total hip and two subregions was measured.

A total of 84 men continuously used loop diuretics between the two time periods, 181 used them intermittently and 3,004 did not use them. After adjusting for other related factors, the average annual rate of decline in total hip bone mineral density was -0.33 percent in non-users, -0.58 percent in intermittent users and -0.78 percent among continuous users.

"Compared with rates of hip bone loss among non-users of diuretics, adjusted rates of loss were about two-fold greater among intermittent loop diuretic users and about 2.5-fold greater among continuous loop diuretic users," the authors write. Findings were similar at the subregions of the hip.

"We conclude that loop diuretic use in older men in associated with increased rates of hip bone loss," the authors write. Future research should address the underlying mechanisms, they note. "Our findings suggest that health care providers should take into account loop diuretic use when evaluating older men for risk factors for bone loss and fracture risk."

Journal reference: Arch Intern Med. 2008;168[7]:735-740.

The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Diuretics Associated With Bone Loss In Older Men." ScienceDaily. ScienceDaily, 17 April 2008. <www.sciencedaily.com/releases/2008/04/080414161538.htm>.
JAMA and Archives Journals. (2008, April 17). Diuretics Associated With Bone Loss In Older Men. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2008/04/080414161538.htm
JAMA and Archives Journals. "Diuretics Associated With Bone Loss In Older Men." ScienceDaily. www.sciencedaily.com/releases/2008/04/080414161538.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins