Featured Research

from universities, journals, and other organizations

Variants Of Vitamin D Receptor Linked To Increased Risk Of Breast Cancer

Date:
April 21, 2008
Source:
BioMed Central/Breast Cancer Research
Summary:
Genetic variations in the body's receptor for vitamin D could increase the risk of breast cancer in post-menopausal women, according to a new study. The researchers explain that vitamin D intake and serum concentrations of its metabolites have been associated with a decreased risk of developing breast cancer. The vitamin plays a known role in controlling calcium levels and influences the differentiation of cells and so could play a part in preventing the runaway proliferation of cells characteristic with cancer.

Genetic variations in the body's receptor for vitamin D could increase the risk of breast cancer in postmenopausal women, according to a new study.

Jenny Chang-Claude of the Division of Cancer Epidemiology, at the German Cancer Research Center, in Heidelberg, and colleagues there and at the Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Germany, undertook a population-based case-control study involving 1,408 patients and 2,612 control individuals.

The researchers explain that vitamin D intake and serum concentrations of its metabolites have been associated with a decreased risk of developing breast cancer. The vitamin plays a known role in controlling calcium levels and influences the differentiation of cells and so could play a part in preventing the runaway proliferation of cells characteristic with cancer.

Previous studies regarding the association between vitamin D and breast cancer have been inconsistent in their conclusions.

Chang-Claude and her colleagues have investigated variations in the gene encoding the vitamin D receptor protein. They found that there were no differences in the biomarker for vitamin D, 25-hydroxyvitamin D, between women with two well-known genetic variations, the polymorphisms FokI and TaqI, and two functional putative variants, VDR-5132 and Cdx2, in the gene for the receptor. Moreover, they found no relationship between the presence of these polymorphisms and overall risk of postmenopausal breast cancer.

However, they found a significant increase in the risk of estrogen receptor (ER) positive tumours among women with the TaqI genetic variant. This suggests the involvement of estrogen metabolism in the anticancer activity of vitamin D.

"Further studies focusing on the influence of genetic variations on vitamin D receptor functionality, activity and concentration are now needed" says Chang-Claude.

Journal reference: Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk. Sascha Abbas, Alexandra Nieters, Jakob Linseisen, Tracy Slanger, Silke Kropp, Elke J Mutschelknauss, Dieter Flesch-Janys and Jenny Chang-Claude. Breast Cancer Research (in press)


Story Source:

The above story is based on materials provided by BioMed Central/Breast Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central/Breast Cancer Research. "Variants Of Vitamin D Receptor Linked To Increased Risk Of Breast Cancer." ScienceDaily. ScienceDaily, 21 April 2008. <www.sciencedaily.com/releases/2008/04/080417084022.htm>.
BioMed Central/Breast Cancer Research. (2008, April 21). Variants Of Vitamin D Receptor Linked To Increased Risk Of Breast Cancer. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2008/04/080417084022.htm
BioMed Central/Breast Cancer Research. "Variants Of Vitamin D Receptor Linked To Increased Risk Of Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/04/080417084022.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins