Featured Research

from universities, journals, and other organizations

Hormone Therapy In Postmenopausal Women Associated With Increased Risk Of Stroke

Date:
April 30, 2008
Source:
JAMA and Archives Journals
Summary:
Postmenopausal women taking hormone therapy appear to have an increased risk of stroke regardless of when they started treatment, according to a new report. Compared to women who had never used hormones, women currently taking hormone therapy had an increased risk for stroke (39 percent for those taking estrogen and 27 percent for those taking estrogen with progestin).

Postmenopausal women taking hormone therapy appear to have an increased risk of stroke regardless of when they started treatment, according to a new article.

"Many controversies remain regarding the risks and benefits of postmenopausal hormone therapy," according to background information in the article. There have been previous studies analyzing the risk of stroke with use of hormone therapy, but these did not determine stroke risk for younger women taking hormone therapy near the onset of menopause.

Francine Grodstein, Sc.D., and colleagues, at Brigham and Women's Hospital (BWH) and Harvard Medical School, Boston, evaluated stroke risk associated with hormone therapy in 121,700 women (age 30 to 55 at the beginning of the study) who participated in the Nurses' Health Study from 1976 to 2004. There were 360 cases of stroke among women who had never used hormones and 414 cases of stroke among women who were currently using hormones.

Compared to women who had never used hormones, women currently taking hormone therapy had an increased risk for stroke (39 percent for those taking estrogen and 27 percent for those taking estrogen with progestin). "This increased risk was observed for women initiating hormone therapy at young ages or near menopause and at older ages or more than 10 years after menopause," the authors write. Taking hormone therapy for less than five years at younger ages was not linked to a clear increase in stroke, possibly due to the small number of cases.

"The incidence of stroke was relatively low in younger women, and the attributable risk in women aged 50 through 54 years indicated approximately an additional two cases of stroke per 10,000 women per year taking hormones," the authors write. There was also a strong relationship found between dose of estrogen and stroke, with larger doses increasing the risk.

"In summary, our findings in the Nurses' Health Study indicate that hormone therapy is associated with an increased risk of stroke, regardless of the hormone regime or the timing of hormone therapy initiation," the authors conclude. "However, in younger women, who are at lower absolute risk of stroke, the attributable risk of stroke owing to hormone use is modest, and our data suggest that risk might be further minimized by lower doses and shorter duration of treatment."

Journal reference: Arch Intern Med. 2008;168[8]:861-866.

The work in this article was supported by grants from the National Institutes of Health.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Hormone Therapy In Postmenopausal Women Associated With Increased Risk Of Stroke." ScienceDaily. ScienceDaily, 30 April 2008. <www.sciencedaily.com/releases/2008/04/080428162540.htm>.
JAMA and Archives Journals. (2008, April 30). Hormone Therapy In Postmenopausal Women Associated With Increased Risk Of Stroke. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2008/04/080428162540.htm
JAMA and Archives Journals. "Hormone Therapy In Postmenopausal Women Associated With Increased Risk Of Stroke." ScienceDaily. www.sciencedaily.com/releases/2008/04/080428162540.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins