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New Insights On Link Between Early Consumption Of Cows' Milk And Type-1 Diabetes

Date:
May 7, 2008
Source:
American Chemical Society
Summary:
Researchers in Maine report a new explanation for the mysterious link between consumption of cows' milk protein in infant formula early in life and an increased risk of later developing Type-1 diabetes. A protein in cow's milk that triggers an unusual immune response appears to be the main culprit, they say.
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Researchers in Maine report a new explanation for the mysterious link between consumption of cows' milk protein in infant formula early in life and an increased risk of later developing Type-1 diabetes. A protein in cow's milk that triggers an unusual immune response appears to be the main culprit, they say.

In the new study, Marcia F. Goldfarb points out that several studies have reported a possible link between the early introduction of cow's milk protein into an infant's diet and subsequent development of the disease. In Type-1 diabetes, the immune system erroneously appears to attack and destroy insulin-producing cells in the pancreas. It usually begins in childhood, requires insulin injections, and afflicts about 800,000 people in the U.S. alone.

Scientists do not understand the link between cow's milk and diabetes. They know, however, that beta-lactoglobulin, a protein present in cow's milk but not found in human breast-milk, is structurally similar to the human protein glycodelin, which controls the production of T-cells. T-cells help guard the body against infection.

Goldfarb describes research on patients with Type-1 diabetes, which suggests that an infant's immature immune system may inadvertently destroy glycodelin in an effort to destroy the similar cow's milk protein, which the system recognizes as foreign. This could result in the overproduction of T-cells, which can attack the insulin-producing cells of the pancreas and trigger diabetes, she says.

The study "Relation of Time of Introduction of Cow Milk Protein to an Infant and Risk of Type-1 Diabetes Mellitus" is scheduled for the June 6 issue of ACS' monthly Journal of Proteome Research.


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The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


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American Chemical Society. "New Insights On Link Between Early Consumption Of Cows' Milk And Type-1 Diabetes." ScienceDaily. ScienceDaily, 7 May 2008. <www.sciencedaily.com/releases/2008/05/080505093047.htm>.
American Chemical Society. (2008, May 7). New Insights On Link Between Early Consumption Of Cows' Milk And Type-1 Diabetes. ScienceDaily. Retrieved May 23, 2015 from www.sciencedaily.com/releases/2008/05/080505093047.htm
American Chemical Society. "New Insights On Link Between Early Consumption Of Cows' Milk And Type-1 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2008/05/080505093047.htm (accessed May 23, 2015).

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