Featured Research

from universities, journals, and other organizations

Early Stage Bone Cells Produce Potential Estrogen Substitute

Date:
May 19, 2008
Source:
Yale University
Summary:
Cells on their way to forming bone also produce an estrogen-like substance that mimics the naturally occurring female sex hormone estradiol. Researchers hope such a molecule might provide some of the benefits but, hopefully, not the health risk of traditional hormonal therapies for menopause and bone loss.

Cells on their way to forming bone also produce an estrogen-like substance that mimics the naturally occurring female sex hormone estradiol, investigators at the Yale School of Medicine reported May 12 in the online edition of the Proceedings of the National Academy of Sciences.

Related Articles


Researchers hope such a molecule might provide some of the benefits but, hopefully, not the health risk of traditional hormonal therapies for menopause and bone loss.

Researchers in the laboratories of Thomas L. McCarthy and Michael Centrella in the Department of Surgery isolated this estrogen-like molecule from rat-derived osteoblasts, or cells that can build bones. As the osteoblasts differentiated in culture, they produced a molecule that the investigators tentatively termed “Ob-SERM.” This substance triggered several of the biochemical responses induced by estrogen receptor activation. The osteoblast-derived molecule, however, was in part functionally and chemically distinct from estradiol, raising hopes that it may be a safer alternative to traditional hormone replacement therapies.

Estradiol plays an important role in maintaining skeletal health by balancing the ongoing processes of bone resorption and bone formation that normally occur throughout life. Restoration of estrogen levels after menopause helps to mitigate some of the more harmful side effects of hormone loss that generally occur during aging. However, therapy with native estradiol has also been linked to increased risk of some kinds of cancers.

Other Yale Medical School researchers who contributed to the study include Mary E. Clough and Caren M. Gundberg in the Department of Orthopaedics and Rehabilitation. The study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Early Stage Bone Cells Produce Potential Estrogen Substitute." ScienceDaily. ScienceDaily, 19 May 2008. <www.sciencedaily.com/releases/2008/05/080515101649.htm>.
Yale University. (2008, May 19). Early Stage Bone Cells Produce Potential Estrogen Substitute. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2008/05/080515101649.htm
Yale University. "Early Stage Bone Cells Produce Potential Estrogen Substitute." ScienceDaily. www.sciencedaily.com/releases/2008/05/080515101649.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins