Featured Research

from universities, journals, and other organizations

Early Stage Bone Cells Produce Potential Estrogen Substitute

Date:
May 19, 2008
Source:
Yale University
Summary:
Cells on their way to forming bone also produce an estrogen-like substance that mimics the naturally occurring female sex hormone estradiol. Researchers hope such a molecule might provide some of the benefits but, hopefully, not the health risk of traditional hormonal therapies for menopause and bone loss.

Cells on their way to forming bone also produce an estrogen-like substance that mimics the naturally occurring female sex hormone estradiol, investigators at the Yale School of Medicine reported May 12 in the online edition of the Proceedings of the National Academy of Sciences.

Researchers hope such a molecule might provide some of the benefits but, hopefully, not the health risk of traditional hormonal therapies for menopause and bone loss.

Researchers in the laboratories of Thomas L. McCarthy and Michael Centrella in the Department of Surgery isolated this estrogen-like molecule from rat-derived osteoblasts, or cells that can build bones. As the osteoblasts differentiated in culture, they produced a molecule that the investigators tentatively termed “Ob-SERM.” This substance triggered several of the biochemical responses induced by estrogen receptor activation. The osteoblast-derived molecule, however, was in part functionally and chemically distinct from estradiol, raising hopes that it may be a safer alternative to traditional hormone replacement therapies.

Estradiol plays an important role in maintaining skeletal health by balancing the ongoing processes of bone resorption and bone formation that normally occur throughout life. Restoration of estrogen levels after menopause helps to mitigate some of the more harmful side effects of hormone loss that generally occur during aging. However, therapy with native estradiol has also been linked to increased risk of some kinds of cancers.

Other Yale Medical School researchers who contributed to the study include Mary E. Clough and Caren M. Gundberg in the Department of Orthopaedics and Rehabilitation. The study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Early Stage Bone Cells Produce Potential Estrogen Substitute." ScienceDaily. ScienceDaily, 19 May 2008. <www.sciencedaily.com/releases/2008/05/080515101649.htm>.
Yale University. (2008, May 19). Early Stage Bone Cells Produce Potential Estrogen Substitute. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2008/05/080515101649.htm
Yale University. "Early Stage Bone Cells Produce Potential Estrogen Substitute." ScienceDaily. www.sciencedaily.com/releases/2008/05/080515101649.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com
Michigan Man Sees Thanks to 'bionic Eye'

Michigan Man Sees Thanks to 'bionic Eye'

AP (Apr. 23, 2014) A legally blind Michigan man is 'seeing something new every day' thanks to a high-tech retinal implant procedure. He's one of the first in the country to receive a 'bionic eye' since the federal government approved the surgery. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins