Featured Research

from universities, journals, and other organizations

Retraining Immune Cells To Kill Tumors

Date:
May 20, 2008
Source:
Journal of Experimental Medicine
Summary:
Tumors escape destruction by immune cells by turning off their tumor killing functions. A team of scientists have now found a way to retrain the impotent cells into potent tumor destroyers.

Immune cells called macrophages can destroy tumor cells by producing inflammatory proteins that are toxic to the tumor. But the environment inside the tumor somehow halts this production and instead causes the cells to make proteins that promote tumor growth.

The new study identifies a protein, called IKK(beta), that drives this pro-tumor switch. This protein normally stimulates protective inflammation.

But in the context of tumors, the study shows, IKK(beta) also blocked the activity of a protein that turns on anti-tumor genes.

When the scientists inactivated IKK(beta) in macrophages from mouse tumors, the tumor-friendly cells went on the attack. These cells also secreted proteins that attracted professional tumor-killing cells that helped to shrink the tumors.

The researchers are now conducting clinical trials to determine whether macrophages from cancer patients can be similarly reprogrammed into tumor killers.


Story Source:

The above story is based on materials provided by Journal of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Experimental Medicine. "Retraining Immune Cells To Kill Tumors." ScienceDaily. ScienceDaily, 20 May 2008. <www.sciencedaily.com/releases/2008/05/080519092208.htm>.
Journal of Experimental Medicine. (2008, May 20). Retraining Immune Cells To Kill Tumors. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2008/05/080519092208.htm
Journal of Experimental Medicine. "Retraining Immune Cells To Kill Tumors." ScienceDaily. www.sciencedaily.com/releases/2008/05/080519092208.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins