Featured Research

from universities, journals, and other organizations

Retraining Immune Cells To Kill Tumors

Date:
May 20, 2008
Source:
Journal of Experimental Medicine
Summary:
Tumors escape destruction by immune cells by turning off their tumor killing functions. A team of scientists have now found a way to retrain the impotent cells into potent tumor destroyers.

Immune cells called macrophages can destroy tumor cells by producing inflammatory proteins that are toxic to the tumor. But the environment inside the tumor somehow halts this production and instead causes the cells to make proteins that promote tumor growth.

Related Articles


The new study identifies a protein, called IKK(beta), that drives this pro-tumor switch. This protein normally stimulates protective inflammation.

But in the context of tumors, the study shows, IKK(beta) also blocked the activity of a protein that turns on anti-tumor genes.

When the scientists inactivated IKK(beta) in macrophages from mouse tumors, the tumor-friendly cells went on the attack. These cells also secreted proteins that attracted professional tumor-killing cells that helped to shrink the tumors.

The researchers are now conducting clinical trials to determine whether macrophages from cancer patients can be similarly reprogrammed into tumor killers.


Story Source:

The above story is based on materials provided by Journal of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Experimental Medicine. "Retraining Immune Cells To Kill Tumors." ScienceDaily. ScienceDaily, 20 May 2008. <www.sciencedaily.com/releases/2008/05/080519092208.htm>.
Journal of Experimental Medicine. (2008, May 20). Retraining Immune Cells To Kill Tumors. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2008/05/080519092208.htm
Journal of Experimental Medicine. "Retraining Immune Cells To Kill Tumors." ScienceDaily. www.sciencedaily.com/releases/2008/05/080519092208.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins