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Fetal Exposure To PCBs Impacts Reproductive Markers Of Children And Grandchildren Of Exposed Animals

Date:
May 27, 2008
Source:
Society for the Study of Reproduction
Summary:
Since the 1962 publication of Silent Spring by Rachel Carson, awareness of how environmental toxicants can impact fertility has increased. Researchers now provide evidence that adverse reproductive effects of toxicants may extend not only to the children of exposed individuals, but also to the next generation.

Since the 1962 publication of Silent Spring by Rachel Carson, awareness of how environmental toxicants can impact fertility has increased.

In a new article, Steinberg and colleagues provide evidence that adverse reproductive effects of toxicants may extend not only to the children of exposed individuals, but also to the next generation.

They treated pregnant rats with a mixture of polychlorinated biphenyls (PCBs) and found that reproductive markers were disrupted not only in the female offspring of these rats, but also in the "grand offspring," which are derived from oocytes present in fetuses of the treated females.

Changes in the second generation included blunting of preovulatory LH release, reduced progesterone concentrations and reduced uterine weights.

The use of low doses of PCBs in this study increases the potential relevance of these findings to reproductive health.


Story Source:

The above story is based on materials provided by Society for the Study of Reproduction. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rebecca M. Steinberg, Deena M. Walker, Thomas E. Juenger, Michael J. Woller, and Andrea C. Gore. Effects of Perinatal Polychlorinated Biphenyls on Adult Female Rat Reproduction: Development, Reproductive Physiology, and Second Generational Effects. Biology of Reproduction. 2008; 78:1091-1101. Published online in BOR-Papers In Press 27 February 2008; DOI 10.1095/biolreprod.107.067249

Cite This Page:

Society for the Study of Reproduction. "Fetal Exposure To PCBs Impacts Reproductive Markers Of Children And Grandchildren Of Exposed Animals." ScienceDaily. ScienceDaily, 27 May 2008. <www.sciencedaily.com/releases/2008/05/080524075256.htm>.
Society for the Study of Reproduction. (2008, May 27). Fetal Exposure To PCBs Impacts Reproductive Markers Of Children And Grandchildren Of Exposed Animals. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2008/05/080524075256.htm
Society for the Study of Reproduction. "Fetal Exposure To PCBs Impacts Reproductive Markers Of Children And Grandchildren Of Exposed Animals." ScienceDaily. www.sciencedaily.com/releases/2008/05/080524075256.htm (accessed April 19, 2014).

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