Featured Research

from universities, journals, and other organizations

Therapies Appear Helpful In Reducing Risk Of Depression Following Stroke

Date:
May 27, 2008
Source:
JAMA and Archives Journals
Summary:
In the year following a stroke, patients who received the medication escitalopram or participated in a problem-solving therapy group had a lower risk of depression compared to patients who received placebo.

In the year following a stroke, patients who received the medication escitalopram or participated in a problem-solving therapy group had a lower risk of depression compared to patients who received placebo.

The annual incidence of stroke exceeds 700,000 in the U.S. Depression occurs in more than half of these patients, according to background information in the article. "Post-stroke depression has been shown in numerous studies to be associated with both impaired recovery in activities of daily living and increased mortality. Prevention of depression thus represents a potentially important goal," the researchers write.

Robert. G. Robinson, M.D., of the University of Iowa, Iowa City, and colleagues assessed the efficacy of the anti-depressant drug escitalopram or problem-solving therapy compared with placebo pills for the prevention of depression among 176 stroke patients. Within three months following the stroke, the patients were randomized for 12 months into one of three groups: escitalopram (n = 59); problem-solving therapy group (n = 59); or placebo (n = 58). The problem-solving therapy group consisted of six treatment sessions and six reinforcement sessions and included patients selecting a problem and going through steps to arrive at a course of action.

The researchers found that participants who received placebo were 4.5 times more likely to develop depression than patients who received escitalopram (22.4 percent vs. 8.5 percent), and 2.2 times more likely to develop depression than patients who received problem-solving therapy (11.9 percent). "Based only on the frequency of depression onset during the one year of treatment, 7.2 acute stroke patients would need to be treated with escitalopram to prevent one case of depression and 9.1 acute stroke patients would need to be treated with problem-solving therapy to prevent one case of depression," the authors write.

An alternative, more conservative method of analyzing the data found that escitalopram was superior to placebo (23.1 percent vs. 34.5 percent), while problem-solving therapy was not significantly better than placebo (30.5 percent vs. 34.5 percent).

There was no significant difference between groups in the frequency of adverse events.

"The clinical implications of our findings are that patients who are given escitalopram or problem-solving therapy following acute stroke may be spared depression and perhaps its adverse consequences," the authors conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robert G. Robinson, MD; Ricardo E. Jorge, MD; David J. Moser, PhD; Laura Acion, MS; Ana Solodkin, PhD; Steven L. Small, PhD, MD; Pasquale Fonzetti, MD, PhD; Mark Hegel, PhD; Stephan Arndt, PhD. Escitalopram and Problem-Solving Therapy for Prevention of Poststroke Depression: A Randomized Controlled Trial. JAMA. 2008;299[20]:2391-2400 [link]

Cite This Page:

JAMA and Archives Journals. "Therapies Appear Helpful In Reducing Risk Of Depression Following Stroke." ScienceDaily. ScienceDaily, 27 May 2008. <www.sciencedaily.com/releases/2008/05/080527183026.htm>.
JAMA and Archives Journals. (2008, May 27). Therapies Appear Helpful In Reducing Risk Of Depression Following Stroke. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/05/080527183026.htm
JAMA and Archives Journals. "Therapies Appear Helpful In Reducing Risk Of Depression Following Stroke." ScienceDaily. www.sciencedaily.com/releases/2008/05/080527183026.htm (accessed July 31, 2014).

Share This




More Mind & Brain News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dieting At A Young Age Might Lead To Harmful Health Habits

Dieting At A Young Age Might Lead To Harmful Health Habits

Newsy (July 30, 2014) Researchers say women who diet at a young age are at greater risk of developing harmful health habits, including eating disorders and alcohol abuse. Video provided by Newsy
Powered by NewsLook.com
It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins