Featured Research

from universities, journals, and other organizations

Hand Bone Mineral Density Is An Effective Predictor Of Mortality In Rheumatoid Arthritis

Date:
June 17, 2008
Source:
European League Against Rheumatism
Summary:
Low bone mineral density in the hand is a valid predictor of overall mortality in patients with rheumatoid arthritis and indicates long-term prognosis, according to a new study. Digital X-ray radiogrammetry demonstrated bone mineral density to be as effective predicting mortality as well-established means of assessment such as radiographic damage and functional disability.

Low bone mineral density in the hand is a valid predictor of overall mortality in patients with rheumatoid arthritis (RA) and indicates long-term prognosis, according to a new study presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France. Digital X-ray radiogrammetry (DXR) demonstrated bone mineral density to be as effective predicting mortality as well-established means of assessment such as radiographic damage and functional disability.

During the study, different standard measures of disease activity were investigated in order to assess their capacity to predict all-cause mortality. Over a period of 27 years (1978 -- 2005), age-sex adjusted proportional hazards models for 84 RA patients, found the following to be significant predictors of mortality:

Bone mineral density in the hand (RR=0.55/1SD, 95% CI 0.35-0.87)

Steinbrocker functional classification (RR=1.86/1SD, 95% CI 1.35-2.56)

The physician's global assessment (RR=1.37/1SD, 95% CI 1.02-1.82)

Erythrocyte sedimentation rate (RR=1.86/1SD, 95% CI 1.41-2.46)

Conversely, during this study, certain measures of rheumatic disease activity, including rheumatoid factor, Larsen index, Ritchie index and the patient's global assessment, were not found to be significant predictors of mortality in RA.

The study's lead researcher, Dr Christina Book of Malmφ University Hospital, Sweden, said: "This long-term study establishes that measurement of bone mineral density in the hand may be an important physical gauge in anticipating the course of rheumatoid arthritis. It offers physicians an effective tool for assessing a patient's disease and so developing the most appropriate individual management plan."

In the study, 152 consecutive patients (119 women, 33 men) with a mean disease duration of 13 years were enrolled. X-rays of the hands at inclusion were available in 108 patients, and in 84 of these, bone mineral density was evaluated by DXR on the same digitised hand X-rays used for scoring radiographic joint damage. Placement of joint prostheses or severe malalignment prevented DXR evaluation in the other 24 patients. Manual measurements, such as dividing the combined cortical thickness by the width of metacarpal II (CCTr) were performed in all 108 patients with X-rays at inclusion. Measures of disease activity and damage at inclusion in the 84 subjects were used to predict mortality by Cox regression models. Furthermore, standardised mortality ratios were computed using the general Swedish population as a benchmark, to assess the overall increased mortality in the group, which was three-folded increased.


Story Source:

The above story is based on materials provided by European League Against Rheumatism. Note: Materials may be edited for content and length.


Cite This Page:

European League Against Rheumatism. "Hand Bone Mineral Density Is An Effective Predictor Of Mortality In Rheumatoid Arthritis." ScienceDaily. ScienceDaily, 17 June 2008. <www.sciencedaily.com/releases/2008/06/080612094701.htm>.
European League Against Rheumatism. (2008, June 17). Hand Bone Mineral Density Is An Effective Predictor Of Mortality In Rheumatoid Arthritis. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2008/06/080612094701.htm
European League Against Rheumatism. "Hand Bone Mineral Density Is An Effective Predictor Of Mortality In Rheumatoid Arthritis." ScienceDaily. www.sciencedaily.com/releases/2008/06/080612094701.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) — You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) — As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) — When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins