Featured Research

from universities, journals, and other organizations

Systems Properties Of Insulin Signaling Revealed

Date:
June 25, 2008
Source:
Public Library of Science
Summary:
Swedish researchers have characterized novel systems properties of insulin signaling in human fat cells. Their mathematical modeling provides further insight into energy level maintenance (via the hormone insulin) within our bodies.

A team of Swedish researchers has characterized novel systems properties of insulin signaling in human fat cells. Their mathematical modeling provides further insight into energy level maintenance (via the hormone insulin) within our bodies.

Hampered insulin function is the cardinal cause of Type 2 diabetes, which currently affects nearly 250 million people worldwide. The disease causes a metabolic malfunction due to incorrect information transfer of insulin concentration in the blood to the internal fluid of cells (the cytosol). This information transfer occurs through a complicated network of protein-protein interactions. The skeleton of the network has been characterized, but systems details, including the relative importance and time-scales of the interactions, were previously unknown.

Due to the complexity of the network, it has proved difficult to achieve such a systems understanding through mere experimental techniques and reasoning. Therefore, the team experimentally collected time-series data from human fat cells in vitro and evaluated various mechanistic explanations by translating the explanations into corresponding mathematical models.

In this study, the modeling indicated that either receptor recycling between the membrane and the cytosol, or feedback from proteins activated further down in the network, are involved in the information transfer during the first minutes after insulin stimulation.

As more detailed data become available, the authors predict that mathematical modeling will become an increasingly important tool for data analysis, and for furthering understanding of insulin signaling and cellular control.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. CITATION: Cedersund G, Roll J, Ulfhielm E, Danielsson A, Tidefelt H, et al. Model-Based Hypothesis Testing of Key Mechanisms in Initial Phase of Insulin Signaling. Comput Biol, 4(6): e1000096. DOI: 10.1371/journal.pcbi.1000096

Cite This Page:

Public Library of Science. "Systems Properties Of Insulin Signaling Revealed." ScienceDaily. ScienceDaily, 25 June 2008. <www.sciencedaily.com/releases/2008/06/080619203254.htm>.
Public Library of Science. (2008, June 25). Systems Properties Of Insulin Signaling Revealed. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2008/06/080619203254.htm
Public Library of Science. "Systems Properties Of Insulin Signaling Revealed." ScienceDaily. www.sciencedaily.com/releases/2008/06/080619203254.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins