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Anti-inflammatory Drug Blocks Brain Plaques

Date:
June 25, 2008
Source:
Journal of Experimental Medicine
Summary:
An anti-inflammatory drug may help restore brain function in patients with Alzheimer's disease, according to an animal study in the Journal of Experimental Medicine.

An anti-inflammatory drug may help restore brain function in patients with Alzheimer's disease, according to an animal study recently published in the Journal of Experimental Medicine.

Brain destruction in Alzheimer's disease is caused by the build-up of a protein called amyloid beta in the brain, which triggers damaging inflammation and the destruction of nerve cells. Scientists had previously shown that preventing individual amyloid beta proteins from sticking to one another minimized brain lesions and protected nerve cells against damage.

The new study--a collaborative effort by researchers in Germany and the US--shows that an anti-inflammatory drug (called CNI-1493) may have the same effect. The drug--already tested in humans for the treatment of inflammatory diseases--protected nerve cells against amyloid beta --induced damage in culture. In mice prone to developing an Alzheimer's-like disease, the drug decreased brain inflammation and improved memory and cognitive function.

Other anti-inflammatory drugs, such as ibuprofen, have been shown to reduce Alzheimer's disease lesions in the brains of rodents, but CNI-1493 appears to be faster and more effective. If these results hold up in humans, CNI-1493 may provide a more effective alternative to current Alzheimer's therapies, which temporarily prolong the function of nerve cells but do not prevent their destruction.


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The above story is based on materials provided by Journal of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Experimental Medicine. "Anti-inflammatory Drug Blocks Brain Plaques." ScienceDaily. ScienceDaily, 25 June 2008. <www.sciencedaily.com/releases/2008/06/080624110952.htm>.
Journal of Experimental Medicine. (2008, June 25). Anti-inflammatory Drug Blocks Brain Plaques. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/06/080624110952.htm
Journal of Experimental Medicine. "Anti-inflammatory Drug Blocks Brain Plaques." ScienceDaily. www.sciencedaily.com/releases/2008/06/080624110952.htm (accessed July 28, 2014).

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