Featured Research

from universities, journals, and other organizations

High Levels Of Urinary Albumin In The Normal Range Predict Hypertension

Date:
June 25, 2008
Source:
American Society of Nephrology
Summary:
Healthy individuals with higher levels of albumin excretion, even levels considered normal, are at increased risk of developing hypertension (high blood pressure), according to a study appearing in the October 2008 issue of the Journal of the American Society Nephrology. The study suggests that to prevent cardiovascular disease, the definition of "normal" urinary albumin excretion should be reconsidered.

Healthy individuals with higher levels of albumin excretion, even levels considered normal, are at increased risk of developing hypertension (high blood pressure), according to a study appearing in the October 2008 issue of the Journal of the American Society Nephrology (JASN). The study suggests that to prevent cardiovascular disease, the definition of “normal” urinary albumin excretion should be reconsidered.

Because kidneys normally prevent large molecules such as albumin from being excreted in the urine, high levels of urinary albumin excretion—called albuminuria—can be an indicator of kidney damage. Albuminuria may also reflect dysfunction of endothelial cells throughout the body, which in turn may be a precursor to hypertension.

A variety of studies have shown that higher levels of urinary albumin excretion, even within the normal range, are associated with cardiovascular disease in individuals with diabetes or hypertension. However, less research has been done in low-risk populations. Therefore, it is unclear whether higher, although normal, levels of albumin in the urine might indicate that generally healthy individuals are at risk of developing cardiovascular disease, a condition that claims more than 800,000 lives each year.

To clarify the issue, Dr. John Forman and his colleagues at the Brigham and Women’s Hospital in Boston, MA, looked at the new development of hypertension among 2,179 women without baseline hypertension or diabetes, and with normal levels of urine albumin, who were enrolled in the Nurses’ Health Studies, which are among the largest and longest running investigations of factors that influence women’s health. The researchers discovered that higher levels of urinary albumin excretion, even within the range considered normal, increased an individual’s risk of developing hypertension. Among older women (median age of 65 years), those with the highest levels of albumin excretion were 76% more likely to develop hypertension than those with the lowest levels. For younger women (median age of 44 years), the risk was 35% higher. These elevated risks held true when factors such body mass index, blood pressure, smoking, and family history of hypertension were taken into account.

The authors conclude that their results, in conjunction with the findings of various other studies, suggest that “it is time to re-evaluate our current concept of ‘normal’ albumin excretion.” Hypertension monitoring and treatment of individuals with higher urine albumin levels, even which are within the currently defined normal range, may be warranted.

This research was supported by five grants from the National Institutes of Health (CA87969, CA50385, DK66574, DK07791, and HL079929-01A2) and a grant from the American Heart Association (0535401T).


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. John P. Forman, Naomi D.L. Fisher, Emily L. Schopick, and Gary C. Curhan. Higher Levels of Albuminuria within the Normal Range Predict Incident Hypertension. J Am Soc Nephrol, Published online June 25, 2008 DOI: 10.1681/ASN.2008010038

Cite This Page:

American Society of Nephrology. "High Levels Of Urinary Albumin In The Normal Range Predict Hypertension." ScienceDaily. ScienceDaily, 25 June 2008. <www.sciencedaily.com/releases/2008/06/080625123002.htm>.
American Society of Nephrology. (2008, June 25). High Levels Of Urinary Albumin In The Normal Range Predict Hypertension. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2008/06/080625123002.htm
American Society of Nephrology. "High Levels Of Urinary Albumin In The Normal Range Predict Hypertension." ScienceDaily. www.sciencedaily.com/releases/2008/06/080625123002.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins