Featured Research

from universities, journals, and other organizations

MRI Technique To ID Microstructural Changes In Asthma

Date:
July 8, 2008
Source:
University of Virginia Health System
Summary:
Scientists have developed a novel magnetic resonance imaging (MRI) technique that -- for the first time ever -- identified microscopic structural damages deep in the lungs of patients with asthma.

Co-registered axial apparent diffusion coefficient (ADC) maps from: a healthy subject at diffusion times of 1 ms and 1.5 s; an asthma subject at diffusion times of 1 ms and 1.5 s; and a COPD subject at diffusion times of 1 ms and 1.5 s. The healthy subject has homogeneously low ADC values at both time scales. The asthmatic has focal areas of elevated ADC values anteriorly that are larger and more conspicuous on the long-time-scale ADC maps. The subject with COPD has diffusely, markedly elevated ADC values.
Credit: Image courtesy of University of Virginia Health System

Chengbo Wang, Ph.D., assistant professor of Radiology has developed a novel magnetic resonance imaging (MRI) technique that – for the first time ever –identified microscopic structural damages deep in the lungs of patients with asthma.

Wang says he and his research team used a special type of magnetic resonance imaging to detect microstructural changes in the lungs. “We found structural alterations in asthmatics, which were not expected. These findings contribute to a new understanding of the pathophysiology of asthma.”

Wang’s study, which will be published in the upcoming July issue of Journal of Magnetic Resonance Imaging, involved 14 healthy volunteers and 14 patients with difficult-to-treat asthma.

The research team polarized helium-3 to make it visible for MR imaging. Then the research subjects inhaled the polarized helium-3 gas, and MR images of the lung were obtained. These images measured how far the helium atoms could move in the lung.

Researchers found that the helium-3 atoms moved a greater distance in the lungs of patients with asthma than in healthy subjects, indicating that there are subtle lung structural differences between asthmatics and healthy volunteers. Wang previously used similar MRI techniques last year to show the first evidence of structural lung damage from secondhand cigarette smoke.

“We had expected to see the opposite effect in asthma due to narrowing of airways. Our unexpected results, however, may reflect alterations at the level of the alveoli or smallest bronchi,” says Wang. Although these findings require more study, he says, they may be the reason why some asthmatics are difficult to treat, and they may be related to “remodeling” in asthma – permanent alterations in lung tissue caused by the disease.

“This study raises new questions about our understanding of asthma,” says Wang. “We hope our further research can help resolve some of these questions and help us better understand and manage this sometimes puzzling disease.”

Wang has received the W.S. Moore Young Investigator Award for Clinical Science from the International Society for Magnetic Resonance in Medicine for this work.


Story Source:

The above story is based on materials provided by University of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University of Virginia Health System. "MRI Technique To ID Microstructural Changes In Asthma." ScienceDaily. ScienceDaily, 8 July 2008. <www.sciencedaily.com/releases/2008/07/080701195911.htm>.
University of Virginia Health System. (2008, July 8). MRI Technique To ID Microstructural Changes In Asthma. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/07/080701195911.htm
University of Virginia Health System. "MRI Technique To ID Microstructural Changes In Asthma." ScienceDaily. www.sciencedaily.com/releases/2008/07/080701195911.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins