Featured Research

from universities, journals, and other organizations

MRI Technique To ID Microstructural Changes In Asthma

Date:
July 8, 2008
Source:
University of Virginia Health System
Summary:
Scientists have developed a novel magnetic resonance imaging (MRI) technique that -- for the first time ever -- identified microscopic structural damages deep in the lungs of patients with asthma.

Co-registered axial apparent diffusion coefficient (ADC) maps from: a healthy subject at diffusion times of 1 ms and 1.5 s; an asthma subject at diffusion times of 1 ms and 1.5 s; and a COPD subject at diffusion times of 1 ms and 1.5 s. The healthy subject has homogeneously low ADC values at both time scales. The asthmatic has focal areas of elevated ADC values anteriorly that are larger and more conspicuous on the long-time-scale ADC maps. The subject with COPD has diffusely, markedly elevated ADC values.
Credit: Image courtesy of University of Virginia Health System

Chengbo Wang, Ph.D., assistant professor of Radiology has developed a novel magnetic resonance imaging (MRI) technique that – for the first time ever –identified microscopic structural damages deep in the lungs of patients with asthma.

Wang says he and his research team used a special type of magnetic resonance imaging to detect microstructural changes in the lungs. “We found structural alterations in asthmatics, which were not expected. These findings contribute to a new understanding of the pathophysiology of asthma.”

Wang’s study, which will be published in the upcoming July issue of Journal of Magnetic Resonance Imaging, involved 14 healthy volunteers and 14 patients with difficult-to-treat asthma.

The research team polarized helium-3 to make it visible for MR imaging. Then the research subjects inhaled the polarized helium-3 gas, and MR images of the lung were obtained. These images measured how far the helium atoms could move in the lung.

Researchers found that the helium-3 atoms moved a greater distance in the lungs of patients with asthma than in healthy subjects, indicating that there are subtle lung structural differences between asthmatics and healthy volunteers. Wang previously used similar MRI techniques last year to show the first evidence of structural lung damage from secondhand cigarette smoke.

“We had expected to see the opposite effect in asthma due to narrowing of airways. Our unexpected results, however, may reflect alterations at the level of the alveoli or smallest bronchi,” says Wang. Although these findings require more study, he says, they may be the reason why some asthmatics are difficult to treat, and they may be related to “remodeling” in asthma – permanent alterations in lung tissue caused by the disease.

“This study raises new questions about our understanding of asthma,” says Wang. “We hope our further research can help resolve some of these questions and help us better understand and manage this sometimes puzzling disease.”

Wang has received the W.S. Moore Young Investigator Award for Clinical Science from the International Society for Magnetic Resonance in Medicine for this work.


Story Source:

The above story is based on materials provided by University of Virginia Health System. Note: Materials may be edited for content and length.


Cite This Page:

University of Virginia Health System. "MRI Technique To ID Microstructural Changes In Asthma." ScienceDaily. ScienceDaily, 8 July 2008. <www.sciencedaily.com/releases/2008/07/080701195911.htm>.
University of Virginia Health System. (2008, July 8). MRI Technique To ID Microstructural Changes In Asthma. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/07/080701195911.htm
University of Virginia Health System. "MRI Technique To ID Microstructural Changes In Asthma." ScienceDaily. www.sciencedaily.com/releases/2008/07/080701195911.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins