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For Coronary Artery Disease Patients, B Vitamins May Not Reduce Cardiovascular Events

Date:
August 22, 2008
Source:
JAMA and Archives Journals
Summary:
In a large clinical trial involving patients with coronary artery disease, use of B vitamins was not effective for preventing death or cardiovascular events, according to a study published in the Aug. 20 issue of JAMA.

In a large clinical trial involving patients with coronary artery disease, use of B vitamins was not effective for preventing death or cardiovascular events, according to a study published in the August 20 issue of JAMA.

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"Observational studies have demonstrated that the concentration of total homocysteine in blood is associated with risk of coronary artery disease and stroke," the authors provide as background information. Plasma total homocysteine levels can be lowered by oral administration of folic acid and vitamin B12. In this study, the authors' objective was "to evaluate the effects of homocysteine-lowering treatment with folic acid plus vitamin B12 on mortality and cardiovascular events."

Marta Ebbing, M.D. of Haukeland University Hospital, Bergen, Norway and colleagues, conducted a randomized controlled study with 3,096 patients in two Norwegian hospitals between 1999 – 2006. Patients were randomly assigned to one of four groups receiving a daily oral dose of one of the following treatments: folic acid, 0.8mg, plus vitamin B12 , 0.4mg, plus vitamin B6 , 40mg (n= 772); folic acid plus vitamin B12 (n = 772); vitamin B6 alone (n = 772); or placebo (n = 780). Patients were scheduled for follow-up visits with an interview, clinical examination, and blood sampling at one month, one year, and at a final study visit. The main outcome measure (primary end point) was a composite of all-cause death, nonfatal acute myocardial infarction (heart attack), acute hospitalization for unstable angina pectoris, and nonfatal thromboembolic stroke.

The study was stopped early because of concerns among the participants about preliminary results from another similar Norwegian study suggesting no benefits from the treatment and an increased risk of cancer from the B vitamins.

"Mean (average) plasma total homocysteine concentration was reduced by 30 percent after 1 year of treatment in the groups receiving folic acid and vitamin B12," the authors report. "During a median (midpoint) 38 months of follow-up, the primary end point was experienced by a total of 422 participants (13.7 percent): 219 participants (14.2 percent) receiving folic acid/vitamin B12 vs. 203 (13.1 percent) not receiving such treatment and 200 participants (13.0 percent) receiving vitamin B6 vs. 222 (14.3 percent) not receiving vitamin B6."

"… we could not detect any preventive effect of intervention with folic acid plus vitamin B12 or with vitamin B6 on mortality or major cardiovascular events among patients with stable coronary artery disease undergoing intensive conventional treatment. We found a numerically lower incidence of stroke and higher incidence of cancer in the groups receiving folic acid, but these observations were not statistically significant," the authors conclude. "Our findings do not support the use of B vitamins as secondary prevention in patients with coronary artery disease."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ebbing et al. Mortality and Cardiovascular Events in Patients Treated With Homocysteine-Lowering B Vitamins After Coronary Angiography: A Randomized Controlled Trial. JAMA The Journal of the American Medical Association, 2008; 300 (7): 795 DOI: 10.1001/jama.300.7.795

Cite This Page:

JAMA and Archives Journals. "For Coronary Artery Disease Patients, B Vitamins May Not Reduce Cardiovascular Events." ScienceDaily. ScienceDaily, 22 August 2008. <www.sciencedaily.com/releases/2008/08/080819170425.htm>.
JAMA and Archives Journals. (2008, August 22). For Coronary Artery Disease Patients, B Vitamins May Not Reduce Cardiovascular Events. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2008/08/080819170425.htm
JAMA and Archives Journals. "For Coronary Artery Disease Patients, B Vitamins May Not Reduce Cardiovascular Events." ScienceDaily. www.sciencedaily.com/releases/2008/08/080819170425.htm (accessed March 31, 2015).

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