Featured Research

from universities, journals, and other organizations

Young Women With Early Form Of Breast Cancer No More Likely To Experience Recurrence Than Older Women

Date:
September 26, 2008
Source:
Fox Chase Cancer Center
Summary:
Young women with DCIS, a common form of early breast cancer that arises in and is confined to the mammary ducts, are presumed more likely to have recurrences than older women with the same diagnosis. But a new study from Fox Chase Cancer Center rebuffs this conventional thinking.

Young women with DCIS, a common form of early breast cancer that arises in and is confined to the mammary ducts, are presumed more likely to have recurrences than older women with the same diagnosis. But a new study from Fox Chase Cancer Center rebuffs this conventional thinking.

Related Articles


"There are discrepancies among past studies that looked at the outcomes of very young women with DCIS treated with radiation, but many suggested a less favorable outcome than for older women," explains Aruna Turaka, MD, a fellow in the Department of Radiation Oncology at Fox Chase. "Because each of these studies reflects diverse factors, including how the cancer was managed by the surgeons and radiation oncologists, we wanted to look at our institution's experience in treating DCIS in this population."

Ductal carcinoma in situ, or DCIS, is generally treated with breast-conserving surgery (lumpectomy) and radiation. At Fox Chase, surgeons will commonly re-excise the tumor site until the pathologists and surgeons have "clear margins," or find no sign of cancer around where the tumor was removed. General radiation guidelines dictate that the entire affected breast be irradiated. At Fox Chase, additional radiation also is delivered to the site where the cancer was removed. This is called a "boost."

For this study, physicians examined the records of 440 patients with DCIS treated from 1978 to 2007 at Fox Chase. Of these, 24 patients were 40 years old or younger. Patients with invasive disease or more than one area involved in the breast were excluded. Re-excision to obtain wider clear margins was used in 62 percent of all patients, and even more often - 75 percent - in patients 40 or younger.

All women received whole-breast radiotherapy and 95 percent also received a radiation boost. Data analyzed included method of presentation, patient and DCIS characteristics, and surgical and adjuvant treatment. The median follow-up was 6.8 years (range 0.2-24) and the median age was 56.5 years. The results of the study were presented today at the 50th annual meeting of the American Society for Therapeutic Radiology and Oncology.

"We didn't find a significant difference in recurrence rates based on age," explains Turaka. "Our study suggests that when treating DCIS with breast-conserving surgery and radiation, very young age plays a smaller role as a contributor to local recurrence than previously suggested."

Local recurrence for all women was 7 percent at 10 years and 8 percent at 15 years. At 15 years, the recurrence rate was 10 percent in patients 40 or younger, 7 percent in those ages 41-54, 11 percent in those ages 55-69, and 4 percent in those 70 and older. The different recurrence rates were not statistically significantly.

Turaka notes, "These results are specific to one institution. The reasons for the low rates of recurrence in young women could be related to the careful patient selection and a high utilization of surgical re-excision and a radiation boost."

In addition to Turaka, other authors include Gary Freedman, MD; Tianyu Li, PhD; Richard Bleicher, MD; Ramona Swaby, MD; Nicos Nicolaou, MD; Lori Goldstein, MD; Elin Sigurdson, MD; and Penny Anderson, MD of Fox Chase. The authors report no disclosures. The study was supported by Fox Chase Cancer Center.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "Young Women With Early Form Of Breast Cancer No More Likely To Experience Recurrence Than Older Women." ScienceDaily. ScienceDaily, 26 September 2008. <www.sciencedaily.com/releases/2008/09/080924151005.htm>.
Fox Chase Cancer Center. (2008, September 26). Young Women With Early Form Of Breast Cancer No More Likely To Experience Recurrence Than Older Women. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2008/09/080924151005.htm
Fox Chase Cancer Center. "Young Women With Early Form Of Breast Cancer No More Likely To Experience Recurrence Than Older Women." ScienceDaily. www.sciencedaily.com/releases/2008/09/080924151005.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins