Featured Research

from universities, journals, and other organizations

How A 'Stuck Accelerator' Causes Cancer Cell Expansion

Date:
September 30, 2008
Source:
Ruhr-Universitaet-Bochum
Summary:
What allows cancer cells to divide uncontrolled? The cellular oncogenes and tumor suppressor genes are analogous to the accelerator and brake pedals in a car. If an oncogene is permanently active, similar to a stuck accelerator in a car, cells divide without restraints and a tumor develops.

The cellular oncogenes and tumor suppressor genes are analogous to the accelerator and brake pedals in a car. If an oncogene is permanently active, similar to a stuck accelerator in a car, cells divide without restraints and a tumor develops.

The c-MYC proto-oncogene is activated aberrantly in about 50% of all tumors. As a result the c-MYC protein is produced in excessive amounts, which in turn activates processes associated with cell proliferation.

A group of research scientists led by Prof. Heiko Hermeking (Institute of Pathology, Ruhr-University Bochum, Germany) has now identified a mechanism that allows c-MYC to drive cellular proliferation in the presence of substances that would lead to a block in cell division in normal cells, as for example chemotherapeutic agents. “In future this knowledge may allow a more specific inhibition of tumor growth” Hermeking hopes.

Attractive target structure for cancer drugs

The c-MYC gene is a nodal point in the regulation of cellular division and is highly expressed in colorectal cancer and many other tumor types. The c-MYC protein is a transcription factor which regulates other genes, which in turn mediate the effects of c-MYC on cell proliferation. “In order to understand the origin of cancer it is therefore important to identify genes and mechanisms that mediate the effects of c-MYC on cells” Prof. Hermeking explained. Because of its central position in the regulation of cell proliferation c-MYC is an attractive target structure for cancer therapeutic agents.

Signaling chain unraveled in detail

Prof. Hermeking’s research team determined how c-MYC promotes proliferation. They were able to demonstrate that c-MYC activates the AP4 gene, which results in the synthesis of AP4 protein. AP4 protein in turn suppresses the formation of a central inhibitor of cellular division (p21) by occupying its regulatory region within the genome. Thereby tumor cells become refractory to substances, e.g. chemotherapeutic agents, which block cell division in normal cells.

Instead of terminating proliferation the tumor cells undergo cell death. Moreover, the scientists discovered that colorectal carcinomas, in contrast to normal colon tissue, generally produce large amounts of the AP4 protein. In the future, the knowledge about this signaling cascade could enable a more targeted prevention of cancer cell proliferation. The project is supported by the German Cancer Aid (Deutsche Krebshilfe e.V.).


Story Source:

The above story is based on materials provided by Ruhr-Universitaet-Bochum. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jung et al. AP4 encodes a c-MYC-inducible repressor of p21. Proceedings of the National Academy of Sciences, 2008; DOI: 10.1073/pnas.0801773105

Cite This Page:

Ruhr-Universitaet-Bochum. "How A 'Stuck Accelerator' Causes Cancer Cell Expansion." ScienceDaily. ScienceDaily, 30 September 2008. <www.sciencedaily.com/releases/2008/09/080926100930.htm>.
Ruhr-Universitaet-Bochum. (2008, September 30). How A 'Stuck Accelerator' Causes Cancer Cell Expansion. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/09/080926100930.htm
Ruhr-Universitaet-Bochum. "How A 'Stuck Accelerator' Causes Cancer Cell Expansion." ScienceDaily. www.sciencedaily.com/releases/2008/09/080926100930.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins