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During Exercise, Human Brain Shifts Into High Gear On 'Alternative Energy'

Date:
October 1, 2008
Source:
Federation of American Societies for Experimental Biology
Summary:
The brain, just like muscles, works harder during strenuous exercise and is fueled by lactate, rather than glucose. This helps explain why the brain is able to work properly when the body's demands for fuel and oxygen are highest. It also goes a step further to show that the brain shifts into a higher gear in terms of activity.

Alternative energy is all the rage in major media headlines, but for the human brain, this is old news. According to a study by researchers from Denmark and The Netherlands, the brain, just like muscles, works harder during strenuous exercise and is fueled by lactate, rather than glucose.

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Not only does this finding help explain why the brain is able to work properly when the body's demands for fuel and oxygen are highest, but it goes a step further to show that the brain actually shifts into a higher gear in terms of activity. This opens doors to entirely new areas of brain research related to understanding lactate's specific neurological effects.

"Now that we know the brain can run on lactate, so to speak, future studies should show us when to use lactate as part of a treatment," said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal. "From an evolutionary perspective, the result of this study is a no-brainer. Imagine what could have or did happen to all of the organisms that lost their wits along with their glucose when running from predators. They were obviously a light snack for the animals able to use lactate."

To reach their conclusion, the researchers looked at research that compared the blood running to and from the heads of volunteers undergoing strenuous exercise. They found that the blood on its way to the brain contained considerably more lactate than blood flowing from the brain. Further investigation showed that the brain was not storing the lactate which had come from the muscles during exercise, but rather using it as fuel. In fact, the brain helped to clear lactate from the circulation, thereby leaving glucose to the muscles that need it for the hard work they were performing.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Quistorff et al. Lactate fuels the human brain during exercise. The FASEB Journal, 2008; 22 (10): 3443 DOI: 10.1096/fj.08-106104

Cite This Page:

Federation of American Societies for Experimental Biology. "During Exercise, Human Brain Shifts Into High Gear On 'Alternative Energy'." ScienceDaily. ScienceDaily, 1 October 2008. <www.sciencedaily.com/releases/2008/09/080930135305.htm>.
Federation of American Societies for Experimental Biology. (2008, October 1). During Exercise, Human Brain Shifts Into High Gear On 'Alternative Energy'. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2008/09/080930135305.htm
Federation of American Societies for Experimental Biology. "During Exercise, Human Brain Shifts Into High Gear On 'Alternative Energy'." ScienceDaily. www.sciencedaily.com/releases/2008/09/080930135305.htm (accessed February 27, 2015).

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