Featured Research

from universities, journals, and other organizations

Optics Of Alzheimer’s Disease

Date:
October 18, 2008
Source:
Optical Society of America
Summary:
One of the hallmarks of Alzheimer’s disease is the formation of plaques made of protein aggregates in the brain tissue. There is still considerable debate among scientists as to whether these plaques are the cause of the neuronal death that occurs in Alzheimer’s or just a by-product of the disease, however.

One of the hallmarks of Alzheimer’s disease is the formation of plaques made of protein aggregates in the brain tissue. There is still considerable debate among scientists as to whether these plaques are the cause of the neuronal death that occurs in Alzheimer’s or just a by-product of the disease, however.

Related Articles


In the last decade, autopsies have revealed that people with the worst dementia often don’t have the worst plaques, and clots and hemorrhages in small blood vessels have also been implicated in the disease.

New optical techniques may allow the link between altered blood flow and Alzheimer’s disease to be studied further by enabling scientists to directly look at the effect of clots in the brain’s microvasculature on the development of Alzheimer’s. Chris Schaffer and his colleagues at Cornell University use tightly focused femtosecond lasers to introduce clots in the microvasculature in the brains of rodents. The laser cuts open the cells lining the blood vessels, triggering natural clotting mechanisms and leading to the formation of an occlusion. The clotting process, as well as the subsequent changes in the brain, can be followed with fluorescence microscopy.

Schaffer and his colleagues are looking at whether putting tiny clots in the microvasculature can exacerbate Alzheimer’s disease. Using transgenic mice that are predisposed to developing early-onset Alzheimer’s disease, they have already shown that clotting a microvessel triggers the formation of new protein plaques. Next they plan to systematically study the effect of these clots on the cognitive decline of the Alzheimer’s mice.

Medical research is a cornerstone of Frontiers in Optics 2008 (FiO), the 92nd Annual Meeting of the Optical Society (OSA), being held Oct. 19-23 at the Riverside Convention Center in Rochester, N.Y. FiO 2008 will take place alongside Laser Science XXIV, the annual meeting of the American Physical Society’s Division of Laser Science. The presentation FTuE4, “Femtosecond Laser-Induced Microvascular Clots Trigger Alzheimer's Disease Pathology.”


Story Source:

The above story is based on materials provided by Optical Society of America. Note: Materials may be edited for content and length.


Cite This Page:

Optical Society of America. "Optics Of Alzheimer’s Disease." ScienceDaily. ScienceDaily, 18 October 2008. <www.sciencedaily.com/releases/2008/10/081010115747.htm>.
Optical Society of America. (2008, October 18). Optics Of Alzheimer’s Disease. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2008/10/081010115747.htm
Optical Society of America. "Optics Of Alzheimer’s Disease." ScienceDaily. www.sciencedaily.com/releases/2008/10/081010115747.htm (accessed February 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, February 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins