HTG is a common clinical problem but rare cause of pancreatitis. It was reported that HTG is independently associated with the severity of AP and plays a role in the aggravation of acute necrotizing pancreatitis patients. However, the role of HTG in modulating disease course of
A research article to be published on July 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Xia from West China Hospital of Sichuan University investigated the effect of admission HTG on the episodes of SAP.
In this study, one hundred and seventy-six patients with SAP were divided into HTG group (n = 45) and control group (n = 131) according to admission triglyceride (TG) ≥ 5.65 mmol/L and < 5.65 mmol/L, respectively. Demographics, etiology, underlying diseases, biochemical parameters, Ranson' s score, acute physiology and chronic heath evaluation II(APACHE II) score, Balthazar's computed tomography (CT) score, complications and mortality werecompared. Correlation between admission TG and 24-hour APACHEⅡscore was analyzed.
Their results show that the incidence of admission hypocalcaemia, a predictable index of SAP, and the 24 hour APACHE II score were higher in the HTG group than in the control group. The complications, such as renal failure, shock and infection, and the mortality were higher in the HTG group than in the control group, indicating that HTG aggravates SAP, leading to systemic complications and a high mortality rate of SAP.
- Deng LH, Xue P, Xia Q, Yang XN, Wan MH. Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis. World Journal of Gastroenterology, 2008; 14 (28): 4558 DOI: 10.3748/wjg.14.4558
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