Featured Research

from universities, journals, and other organizations

Breast Cancer Common Among Women With Family History But Without BRCA1 Or BRCA2

Date:
November 26, 2008
Source:
American Association for Cancer Research
Summary:
New data assesses breast cancer risk among women with a strong family history of breast cancer, but without a BRCA1 or BRCA2 mutation. This may facilitate earlier detection and prevention among high-risk women.

New data presented at the American Association for Cancer Research's Seventh Annual International Frontiers in Cancer Prevention Research meeting outlines new data, which assesses breast cancer risk among women with a strong family history of breast cancer, but without a BRCA1 or BRCA2 mutation. This may facilitate earlier detection and prevention among high-risk women.

The study, conducted at the University of Toronto, showed that women with a significant family history of breast cancer remain at increased risk for developing the disease, despite having negative BRCA1 and BRCA2 gene mutations. These mutations typically signal a need for preventive treatment. The excess risk was about four-fold higher than that of average women.

"In clinical practice we often see families with a significant history of breast cancer and negative BRCA1 and BRCA2 tests, and it is often difficult to counsel them about their risk without this information," said Steven Narod, M.D., the study's senior author. "It is clear that genes are involved, but it is hard to be more specific."

Narod, who holds the Canada Research Chair in breast cancer at the University of Toronto and Women's College Research Institute, said this new data would help physicians counsel their patients. "Now when we see families such as this, we will be able to offer better advice about their actual risk. It is clear to me that the risk is high enough that we need to discuss options such as breast MRI for screening and chemoprevention with tamoxifen or raloxifene." said Narod.

Narod and his team of researchers followed 1,492 women from 365 families with negative BRCA1 and BRCA2 genetic mutations for a minimum of five years. These women had a family history of either two or more cases of breast cancer among close relatives under the age of 50 or three cases among close relatives at any age.

Breast cancer rates among these women were compared with control rates found in local breast cancer registries, and researchers noted a 4.3-fold increase.

The highest relative risk was among women under the age of 40, where the increased risk was nearly 15 times higher. Absolute risk was highest among women age 50 to 70 at one percent per year compared with 0.4 percent per year among women between the ages of 30 and 50. This translates into about 30 to 40 percent over their lifetime.

"For all these women, based on what we've identified, tamoxifen would be a good option, as well as breast screening MRI," said Narod. "Our hope is to be able to prevent or pick up on breast cancer early enough to stop patients from dying. We will see what patients decide to do with this advice." In the future, we will follow women like this closely to evaluate the best methods of prevention.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Breast Cancer Common Among Women With Family History But Without BRCA1 Or BRCA2." ScienceDaily. ScienceDaily, 26 November 2008. <www.sciencedaily.com/releases/2008/11/081117103647.htm>.
American Association for Cancer Research. (2008, November 26). Breast Cancer Common Among Women With Family History But Without BRCA1 Or BRCA2. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/11/081117103647.htm
American Association for Cancer Research. "Breast Cancer Common Among Women With Family History But Without BRCA1 Or BRCA2." ScienceDaily. www.sciencedaily.com/releases/2008/11/081117103647.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins