Featured Research

from universities, journals, and other organizations

Increased Calcium Sensitivity In The Heart Can Make For An Irregular Heartbeat

Date:
November 28, 2008
Source:
Journal of Clinical Investigation
Summary:
New mouse studies, by Björn C. Knollmann and colleagues, at Vanderbilt Medical Center, Nashville, have uncovered a potential new molecular mechanism to explain why some individuals suffer irregular heartbeats that can cause sudden death. The results suggest a potential new target for drugs that would be beneficial to those at risk.

New mouse studies, by Björn C. Knollmann and colleagues, at Vanderbilt Medical Center, Nashville, have uncovered a potential new molecular mechanism to explain why some individuals suffer irregular heartbeats that can cause sudden death. The results suggest a potential new target for drugs that would be beneficial to those at risk.

Sudden cardiac death caused by irregular heartbeats (cardiac arrhythmias) is responsible for 10% of all deaths in the US. In some individuals anatomical abnormalities in the heart (such as hypertrophic cardiomyopathy, a disease of the muscle of the heart characterized by a portion of the muscle being thickened) increase the risk of irregular heartbeats and sudden death.

In the study, mice expressing mutant forms of the protein troponin T that cause hypertrophic cardiomyopathy in humans were found to have an increased risk of irregular heartbeats. Detailed analysis indicated that the enhanced susceptibility to irregular heartbeats was a result of increased sensitivity of a key component of the heart contractile units (specifically the myofilaments) to Ca2+.

As the drug blebbistatin, which decreases the sensitivity of myofilaments to Ca2+, provided the mice with substantial protection from irregular heartbeats, the authors suggest that normalizing myofilament Ca2+sensitivity in individuals with hypertrophic cardiomyopathy might help protect them from irregular heartbeats and sudden death.

In an accompanying commentary, Céline Fiset and Wayne R. Giles provide insight into the complexities of the new data, highlighting their significance.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Baudenbacher et al. Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI36642
  2. Fiset et al. Cardiac troponin T mutations promote life-threatening arrhythmias. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI37787

Cite This Page:

Journal of Clinical Investigation. "Increased Calcium Sensitivity In The Heart Can Make For An Irregular Heartbeat." ScienceDaily. ScienceDaily, 28 November 2008. <www.sciencedaily.com/releases/2008/11/081120173129.htm>.
Journal of Clinical Investigation. (2008, November 28). Increased Calcium Sensitivity In The Heart Can Make For An Irregular Heartbeat. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2008/11/081120173129.htm
Journal of Clinical Investigation. "Increased Calcium Sensitivity In The Heart Can Make For An Irregular Heartbeat." ScienceDaily. www.sciencedaily.com/releases/2008/11/081120173129.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) — Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) — Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) — Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins