Featured Research

from universities, journals, and other organizations

Fractional Dose Of Scarce Meningitis Vaccine May Be Effective In Outbreak Control

Date:
December 6, 2008
Source:
Public Library of Science
Summary:
A partial dose of a commonly used vaccine against meningitis may be as effective as a full dose, according to new research. Fractional dosing would enable large-scale vaccination campaigns during epidemics, especially at a time of global vaccine shortages.

A partial dose of a commonly used vaccine against meningitis may be as effective as a full dose, according to new research published December 2 in the open-access journal PLoS Neglected Tropical Diseases. Fractional dosing would enable large-scale vaccination campaigns during epidemics, especially at a time of global vaccine shortages.

In the study, immune responses in patients receiving smaller doses of a meningitis vaccine were comparable to a full dose. The study's findings contributed to a 2007 WHO recommendation that a fractional dosing strategy be utilized in the context of severe vaccine shortages during a meningitis epidemic.

Meningitis epidemics occur nearly every year across a wide swath of sub-Saharan Africa, dubbed the "Meningitis Belt". Outbreaks are caused by specific bacterial strains (primarily Neisseria meningitidis serogroups A and W135), which current vaccines target. Because of global shortages of meningococcal vaccines, the researchers investigated the use of lower doses.

In a 2004 randomized clinical trial of 750 healthy volunteers (2-19 years old) in Uganda, immune response, assessed by serum bactericidal activity (SBA), was measured for 1/5 and 1/10 doses against a full dose. SBA response and safety/tolerability using 1/5 dose were comparable to full dose for three serogroups (A, Y, W135), though not a fourth (C).

Although another measure of immune response, IgG level, was lower for fractional doses, the aim of mass vaccination during epidemics is short-term protection, which is best measured by SBA.

Because of the lack of vaccine producers and publicly financed vaccine stock, current supplies will likely be insufficient in the case of a large-scale epidemic. Efforts are under way to increase production, but this will not be soon enough if a massive epidemic occurs in the coming months as meningitis season nears. If a large-scale outbreak occurs, WHO will need to quickly advise countries on the fractionate strategy before vaccine supplies run out, the authors say.

"In view of the current shortage of meningococcal vaccines for Africa, the use of 1/5 fractional doses should be considered as an alternative in mass vaccination campaigns," the authors say.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Guerin et al. Immunogenicity of Fractional Doses of Tetravalent A/C/Y/W135 Meningococcal Polysaccharide Vaccine: Results from a Randomized Non-Inferiority Controlled Trial in Uganda. PLoS Neglected Tropical Diseases, 2008; 2 (12): e342 DOI: 10.1371/journal.pntd.0000342

Cite This Page:

Public Library of Science. "Fractional Dose Of Scarce Meningitis Vaccine May Be Effective In Outbreak Control." ScienceDaily. ScienceDaily, 6 December 2008. <www.sciencedaily.com/releases/2008/12/081201233450.htm>.
Public Library of Science. (2008, December 6). Fractional Dose Of Scarce Meningitis Vaccine May Be Effective In Outbreak Control. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2008/12/081201233450.htm
Public Library of Science. "Fractional Dose Of Scarce Meningitis Vaccine May Be Effective In Outbreak Control." ScienceDaily. www.sciencedaily.com/releases/2008/12/081201233450.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Ebola Patient Told Hospital He Was from Liberia

Ebola Patient Told Hospital He Was from Liberia

AP (Oct. 1, 2014) The first Ebola patient diagnosed in the U.S. initially went to a Dallas emergency room last week but was sent home, despite telling a nurse that he had been in disease-ravaged West Africa, the hospital acknowledged Wednesday. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins