Featured Research

from universities, journals, and other organizations

Fractional Dose Of Scarce Meningitis Vaccine May Be Effective In Outbreak Control

Date:
December 6, 2008
Source:
Public Library of Science
Summary:
A partial dose of a commonly used vaccine against meningitis may be as effective as a full dose, according to new research. Fractional dosing would enable large-scale vaccination campaigns during epidemics, especially at a time of global vaccine shortages.

A partial dose of a commonly used vaccine against meningitis may be as effective as a full dose, according to new research published December 2 in the open-access journal PLoS Neglected Tropical Diseases. Fractional dosing would enable large-scale vaccination campaigns during epidemics, especially at a time of global vaccine shortages.

Related Articles


In the study, immune responses in patients receiving smaller doses of a meningitis vaccine were comparable to a full dose. The study's findings contributed to a 2007 WHO recommendation that a fractional dosing strategy be utilized in the context of severe vaccine shortages during a meningitis epidemic.

Meningitis epidemics occur nearly every year across a wide swath of sub-Saharan Africa, dubbed the "Meningitis Belt". Outbreaks are caused by specific bacterial strains (primarily Neisseria meningitidis serogroups A and W135), which current vaccines target. Because of global shortages of meningococcal vaccines, the researchers investigated the use of lower doses.

In a 2004 randomized clinical trial of 750 healthy volunteers (2-19 years old) in Uganda, immune response, assessed by serum bactericidal activity (SBA), was measured for 1/5 and 1/10 doses against a full dose. SBA response and safety/tolerability using 1/5 dose were comparable to full dose for three serogroups (A, Y, W135), though not a fourth (C).

Although another measure of immune response, IgG level, was lower for fractional doses, the aim of mass vaccination during epidemics is short-term protection, which is best measured by SBA.

Because of the lack of vaccine producers and publicly financed vaccine stock, current supplies will likely be insufficient in the case of a large-scale epidemic. Efforts are under way to increase production, but this will not be soon enough if a massive epidemic occurs in the coming months as meningitis season nears. If a large-scale outbreak occurs, WHO will need to quickly advise countries on the fractionate strategy before vaccine supplies run out, the authors say.

"In view of the current shortage of meningococcal vaccines for Africa, the use of 1/5 fractional doses should be considered as an alternative in mass vaccination campaigns," the authors say.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Guerin et al. Immunogenicity of Fractional Doses of Tetravalent A/C/Y/W135 Meningococcal Polysaccharide Vaccine: Results from a Randomized Non-Inferiority Controlled Trial in Uganda. PLoS Neglected Tropical Diseases, 2008; 2 (12): e342 DOI: 10.1371/journal.pntd.0000342

Cite This Page:

Public Library of Science. "Fractional Dose Of Scarce Meningitis Vaccine May Be Effective In Outbreak Control." ScienceDaily. ScienceDaily, 6 December 2008. <www.sciencedaily.com/releases/2008/12/081201233450.htm>.
Public Library of Science. (2008, December 6). Fractional Dose Of Scarce Meningitis Vaccine May Be Effective In Outbreak Control. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2008/12/081201233450.htm
Public Library of Science. "Fractional Dose Of Scarce Meningitis Vaccine May Be Effective In Outbreak Control." ScienceDaily. www.sciencedaily.com/releases/2008/12/081201233450.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins