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Maternal Exposure To Folic Acid Antagonists Increases Risks Of Certain Adverse Pregnancy Outcomes

Date:
December 5, 2008
Source:
Canadian Medical Association Journal
Summary:
Exposure to folic acid antagonists during pregnancy is associated with a higher risk of placenta-mediated adverse outcomes such as preeclampsia, placental abruption, fetal growth restriction or fetal death reports a retrospective cohort study.
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Exposure to folic acid antagonists during pregnancy is associated with a higher risk of placenta-mediated adverse outcomes such as preeclampsia, placental abruption, fetal growth restriction or fetal death reports a retrospective cohort study.

Folic acid antagonists include a broad range of drugs used to treat epilepsy, mood disorders, hypertension and infections. As approximately 50% of pregnancies in industrialized countries like Canada are unplanned, there is a risk of unintended exposure to these medications.

The study, conducted by researchers from Ottawa, Montreal, Saskatoon and Hunan, China looked at 14 982 women who had taken folic acid antagonists one year prior to delivery and 59 825 women who did not. Dr. Shi Wu Wen and co- researchers found that maternal exposure to folic acid antagonists was associated with a slightly higher risk of adverse pregnancy outcomes. They suggest re-classifying some folic acid antagonists and recommend increased folic acid supplements for women requiring folic acid antagonists during pregnancy.

In a related commentary, Dr. Joel Ray suggests the research study presents some "thought-provoking findings, but the results may not be ready for adoption by clinical practitioners or drug policy makers." He cites some real concerns with the study design and the need for clinically relevant finding as cautions about translating findings into practice.


Story Source:

The above post is reprinted from materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shi Wu Wen et al. Maternal exposure to folic acid antagonists and placenta-mediated adverse pregnancy outcomes. Canadian Medical Association Journal, Dec 2, 2008 DOI: 10.1503/cmaj.080859

Cite This Page:

Canadian Medical Association Journal. "Maternal Exposure To Folic Acid Antagonists Increases Risks Of Certain Adverse Pregnancy Outcomes." ScienceDaily. ScienceDaily, 5 December 2008. <www.sciencedaily.com/releases/2008/12/081202080821.htm>.
Canadian Medical Association Journal. (2008, December 5). Maternal Exposure To Folic Acid Antagonists Increases Risks Of Certain Adverse Pregnancy Outcomes. ScienceDaily. Retrieved September 4, 2015 from www.sciencedaily.com/releases/2008/12/081202080821.htm
Canadian Medical Association Journal. "Maternal Exposure To Folic Acid Antagonists Increases Risks Of Certain Adverse Pregnancy Outcomes." ScienceDaily. www.sciencedaily.com/releases/2008/12/081202080821.htm (accessed September 4, 2015).

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