Featured Research

from universities, journals, and other organizations

What’s Good For The Mouse Is Good For The Monkey: Skin Cells Reprogrammed Into Stem Cells

Date:
December 4, 2008
Source:
Cell Press
Summary:
Scientists have successfully created the first induced pluripotent stem cell lines from adult monkey skin cells. The research, published in the journal Cell Stem Cell, demonstrates that the method of direct reprogramming is conserved among species and may be useful for creation of clinically valuable primate models for human diseases.

Scientists have successfully created the first induced pluripotent stem (iPS) cell lines from adult monkey skin cells. The research, published by Cell Press in the December issue of the journal Cell Stem Cell, demonstrates that the method of direct reprogramming is conserved among species and may be useful for creation of clinically valuable primate models for human diseases.

Although previous work has shown that induction of four key transcription factors can reprogram adult mouse and human skin cells into iPS cells, creation of iPS cells in other species has not been demonstrated. "We sought to generate monkey iPS cells from skin cells isolated an adult male rhesus macaque using the predicted monkey transcription factors OCT4, SOX2, KLF4 and c-MYC," explains Dr. Hongkui Deng from the Key Laboratory of Cell Proliferation and Differentiation at Peking University in Beijing, China.

Dr. Deng and colleagues used retroviruses expressing these four factors to infect adult monkey skin cells. This technique led to creation of cells which displayed multiple hallmarks of embryonic stem (ES) cells. Specifically, the cells exhibited physical characteristics associated with ES cells, expressed genes appropriate for ES cells and possessed the ability to develop into multiple types of differentiated cells. These results reveal that monkey iPS cells can be generated using the same four transcription factors that have been used to successfully create mouse and human iPS cells.

The work has multiple exciting applications. "As the rhesus macaque is the most relevant primate model for most human diseases, highly efficient generation of monkey iPS cells would allow investigation of the treatment of various diseases in this model," offers Dr. Deng. "In addition, direct reprogramming with the four transcription factors could be a universal strategy for generating iPS cells in other species."

The researchers include Haisong Liu, Peking University, Beijing, China, Shenzhen Graduate School of Peking University, Shenzhen, China; Fangfang Zhu, Peking University, Beijing, China, Shenzhen Graduate School of Peking University, Shenzhen, China; Jun Yong, Peking University, Beijing, China, Shenzhen Graduate School of Peking University, Shenzhen, China; Pengbo Zhang, Peking University, Beijing, China; Pingping Hou, Peking University, Beijing, China;Honggang Li, Peking University, Beijing, China; Wei Jiang, Peking University, Beijing, China; Jun Cai, Peking University, Beijing, China; Meng Liu, Peking University, Beijing, China, Shenzhen Graduate School of Peking University, Shenzhen, China; Kai Cui, Peking University, Beijing, China; Xiuxia Qu, Peking University, Beijing, China;Tingting Xiang, Peking University, Beijing, China; Danyu Lu, Peking University, Beijing, China; Xiaochun Chi, Peking University, Beijing, China; Ge Gao, Peking University, Beijing, China; Weizhi Ji, Chinese Academy of Sciences, Kunming, China; Mingxiao Ding, Peking University, Beijing, China; and Hongkui Deng, Peking University, Beijing, China, Shenzhen Graduate School of Peking University, Shenzhen, China.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "What’s Good For The Mouse Is Good For The Monkey: Skin Cells Reprogrammed Into Stem Cells." ScienceDaily. ScienceDaily, 4 December 2008. <www.sciencedaily.com/releases/2008/12/081203131031.htm>.
Cell Press. (2008, December 4). What’s Good For The Mouse Is Good For The Monkey: Skin Cells Reprogrammed Into Stem Cells. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2008/12/081203131031.htm
Cell Press. "What’s Good For The Mouse Is Good For The Monkey: Skin Cells Reprogrammed Into Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2008/12/081203131031.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins