Featured Research

from universities, journals, and other organizations

Prostate Cancer Screening Program Shows High Compliance And Consistent Results In More Than 38,000 Men

Date:
December 15, 2008
Source:
Wiley - Blackwell
Summary:
Just under five per cent of the men who took part in the prostate cancer element of the USA's largest ever cancer screening trial were diagnosed with the disease and the majority of those were picked up by screening programs.

Just under five per cent of the men who took part in the prostate cancer element of the USA’s largest ever cancer screening trial were diagnosed with the disease and the majority of those were picked up by screening programmes, according to research published in the December issue of the UK-based urology journal BJU International.

A total of 154,934 men and women aged from 55 to 74 took part in the multi-centre Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial and 38,349 men were selected at random to receive a prostate-specific antigen (PSA) test and a digital rectal examination (DRE).

“The aim of the study is to determine the impact of annual PSA and DRE screening on prostate cancer mortality by comparing the men who were screened with men undergoing standard medical care without screening” explains Professor Gerald Andriole, Chief of the Division of Urology at Washington University School of Medicine, USA.

“This paper reports the findings from the first three of the five annual follow-up screening rounds. It looks at whether the men continued to take part in the screening programme and examines the characteristics of the cancers that were discovered.”

Ten screening centres took part in the research, which was funded by the National Cancer Institute.

Key test findings included:

  • The majority of the men included in the study complied with the PSA and DRE tests - 89% complied with both tests at baseline and this figure was 85% by year three.
  • Approximately one in seven men received either a positive PSA or DRE test at the baseline, one, two and three year screenings (14%, 13.5%, 14.4% and 15.1% respectively).
  • An average of 8% of the men had a PSA positive result of more than 4ng/mL over the four tests (7.9%, 7.7%, 8.2% and 8.8% respectively).
  • Just over 7% of the men had a positive DRE result when the four tests were averaged out (7.2%, 6.8%, 7.3% and 7.6% respectively).
  • Both tests were positive in just over 1% of cases (1.2%, 1%, 1.1% and 1.2% respectively).

Key cancer findings included:

  • 1,902 men (4.9%) were diagnosed with prostate cancer and just over 84% of these (1,603) were picked up as a result of PSA or DRE screening.
  • Just over a third of the cancers were picked up at baseline (34.2%). Cancers picked up at this stage tended to be more serious than cancers picked up later in the screening programme. For example, 5.8% of the cancers at baseline were stages three or four, compared with 1.5% in year three.
  • Cancers picked up at baseline were also more likely to have a higher Gleason score, meaning that the cancer was more aggressive and more likely to be fatal. 34% had a Gleason score of seven to ten at baseline, compared with an average of 25.6% in years one to three.
  • 84% of the men who were diagnosed as a result of PSA screening had a PSA of more than 4ng/mL.
  • But not all the cancer patients had an elevated PSA. DRE picked up a further 16% of cancer cases in patients who had a PSA of less than 4ng/mL.
  • The screening programme picked up 16 cancers per thousand men screened at baseline, 11.5 in year one, 10.8 in year two and 11.1 in year three.

“There has been much debate about the benefits of PSA screening in the United States” says Professor Andriole. “For example the American Cancer Society, the American Urological Association and the National Comprehensive Cancer Network recommend that normal risk men receive annual PSA screening with DRE from the age of 50.

“However, the US Preventative Services Task Force and the American College of Physicians - American Society of Internal Medicine do not recommend screening because they feel that clear benefits have not been demonstrated.

“Our research found that compliance was high with both PSA and DRE screening. It also showed that PSA and DRE screening consistently detected new cases of prostate cancer and that these became less and less aggressive as the screening programme progressed.

“Longer follow-up of this study group is necessary to link the test results to death rates and determine the benefits of PSA and DRE screening in reducing deaths due to prostate cancer.”


Story Source:

The above story is based on materials provided by Wiley - Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley - Blackwell. "Prostate Cancer Screening Program Shows High Compliance And Consistent Results In More Than 38,000 Men." ScienceDaily. ScienceDaily, 15 December 2008. <www.sciencedaily.com/releases/2008/12/081215074638.htm>.
Wiley - Blackwell. (2008, December 15). Prostate Cancer Screening Program Shows High Compliance And Consistent Results In More Than 38,000 Men. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/12/081215074638.htm
Wiley - Blackwell. "Prostate Cancer Screening Program Shows High Compliance And Consistent Results In More Than 38,000 Men." ScienceDaily. www.sciencedaily.com/releases/2008/12/081215074638.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins