Featured Research

from universities, journals, and other organizations

Hormones Increase Frequency Of Inherited Form Of Migraine In Women

Date:
December 26, 2008
Source:
Journal of Clinical Investigation
Summary:
Familial hemiplegic migraine (FHM) is an inherited form of severe migraine that is accompanied by visual disturbances known as aura. As with other types of migraine, it affects women more frequently than men. New research in mice has now provided insight into events in the brain that lead to FHM and demonstrated that hormones produced by the ovaries increase susceptibility to FHM.

Familial hemiplegic migraine (FHM) is an inherited form of severe migraine that is accompanied by visual disturbances known as aura. As with other types of migraine, it affects women more frequently than men. Most cases of FHM are caused by mutations in the CACNA1A gene, but whether these lead to spreading depression, the event in the brain that suppresses nerve cell activity and that has been linked to nongenetic forms of migraine with aura, has not been determined.

Related Articles


However, Cenk Ayata and colleagues, at Massachusetts General Hospital, have now generated data in mice that address this issue as well as provide insight into the reasons why FHM affects women more frequently than men.

In the study, mice expressing either one of two different CACNA1A mutations that lead to FHM in humans were found to have an increased susceptibility to spreading depression. Interestingly, the mutation linked to more severe FHM caused a greater increase in susceptibility to spreading depression than the mutation linked to a milder form of FHM. As with humans, female mice were more susceptible to spreading depression than male mice. This difference was reversed if the female mice had their ovaries removed, and then partially restored by replacement of the hormone estrogen. The authors therefore conclude that both genetic and hormonal factors modulate an individual's susceptibility to migraines with aura.

In an accompanying commentary, Takahiro Takano and Maiken Nedergaard, at the University of Rochester, Rochester, explain the importance of these data, highlighting the implications for the serious complications that can accompany FHM.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eikermann-Haerter et al. Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. Journal of Clinical Investigation, Dec 22, 2008; DOI: 10.1172/JCI36059

Cite This Page:

Journal of Clinical Investigation. "Hormones Increase Frequency Of Inherited Form Of Migraine In Women." ScienceDaily. ScienceDaily, 26 December 2008. <www.sciencedaily.com/releases/2008/12/081222221447.htm>.
Journal of Clinical Investigation. (2008, December 26). Hormones Increase Frequency Of Inherited Form Of Migraine In Women. ScienceDaily. Retrieved April 25, 2015 from www.sciencedaily.com/releases/2008/12/081222221447.htm
Journal of Clinical Investigation. "Hormones Increase Frequency Of Inherited Form Of Migraine In Women." ScienceDaily. www.sciencedaily.com/releases/2008/12/081222221447.htm (accessed April 25, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, April 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Judge OKs 65-Year Deal Over NFL Concussions

Judge OKs 65-Year Deal Over NFL Concussions

AP (Apr. 23, 2015) A judge has approved a potential $1 billion plan to resolve thousands of NFL concussion lawsuits filed by retired players. The NFL expects 6,000 of nearly 20,000 retired players to suffer from Alzheimer&apos;s disease or moderate dementia someday.(April 23) Video provided by AP
Powered by NewsLook.com
Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Newsy (Apr. 21, 2015) The use of complex tools has often been seen as a defining characteristic of humanity, but that notion is now in question. Video provided by Newsy
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins