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Potential New Molecule To Prevent Inflammation

Date:
January 15, 2009
Source:
American Journal of Pathology
Summary:
Scientists have identified a potential new molecule that inhibits inflammation, receptor for formylated peptides-2 (FPR-2).

Dr. Sonia Oliani and colleagues at São Paulo State University have identified a potential new molecule that inhibits inflammation, receptor for formylated peptides-2 (FPR-2).

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Inflammation of the peritoneum is characterized by severe abdominal pain. This inflammation can be prevented by annexin A1, which inhibits the migration of inflammation-inducing white blood cells into the affected area.

In this study, Gastardelo et al examined the identities of the receptors responsible for the anti-inflammatory effects of annexin A1 in a mouse model of peritonitis. FPR family members had been previously shown to interact with annexin A1. Yet FPR-1-deficient mice, unlike annexin A1-null mice, did not have increased white blood cell recruitment. Instead, annexin A1 colocalized with another FPR family member, FPR-2.

The data by Gastardelo et al "provide in vivo evidence that endogenous annexin A1 is an essential mediator for homeostasis during the inflammatory process." They go on to propose "that these experimental findings may impact the development of novel therapeutics based on the anti-migratory actions of annexin A1."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gastardelo TS, Damazo AS, Dalli J, Flower RJ, Perretti M, Oliani SM. Functional and ultrastrutural analysis of annexin A1 and its receptor in extravasting neurophils during inflammation. Am J Pathol, 2009, 174:177-183

Cite This Page:

American Journal of Pathology. "Potential New Molecule To Prevent Inflammation." ScienceDaily. ScienceDaily, 15 January 2009. <www.sciencedaily.com/releases/2008/12/081230074827.htm>.
American Journal of Pathology. (2009, January 15). Potential New Molecule To Prevent Inflammation. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2008/12/081230074827.htm
American Journal of Pathology. "Potential New Molecule To Prevent Inflammation." ScienceDaily. www.sciencedaily.com/releases/2008/12/081230074827.htm (accessed October 24, 2014).

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