Featured Research

from universities, journals, and other organizations

Antibodies Produced Within Joints In Rheumatoid Arthritis

Date:
January 13, 2009
Source:
Public Library of Science
Summary:
Antibodies produced within the joints themselves may be responsible for joint damage in rheumatoid arthritis, according to new research.

Antibodies produced within the joints themselves may be responsible for joint damage in rheumatoid arthritis, according to new research published in PLoS Medicine.

Studying joint biopsies from people with rheumatoid arthritis, Costantino Pitzalis of Barts and the London School of Medicine and colleagues found that tiny structures in the joint lining mimic key functions of antibody-producing lymph nodes, and can support the production of specific antibodies that may play a role in joint destruction.

They found that these processes continued after joint tissue bearing the lymphoid structures was transplanted into mice without immune systems of their own, indicating that potentially destructive antibody production within joints can proceed independently of the body's lymph nodes.

In an accompanying Perspective article, Rene E. M. Toes and Tom W. J. Huizinga of Leiden University Medical Center, who were not involved in the research, note that these results provide a rationale to target lymphoid structures in the joints as a new treatment modality for rheumatoid arthritis.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal References:

  1. Humby et al. Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium. PLoS Medicine, 2009; 6 (1): e1 DOI: 10.1371/journal.pmed.0060001
  2. Toes et al. Autoimmune Responses in the Rheumatoid Synovium. PLoS Medicine, 2009; 6 (1): e9 DOI: 10.1371/journal.pmed.1000009

Cite This Page:

Public Library of Science. "Antibodies Produced Within Joints In Rheumatoid Arthritis." ScienceDaily. ScienceDaily, 13 January 2009. <www.sciencedaily.com/releases/2009/01/090112212449.htm>.
Public Library of Science. (2009, January 13). Antibodies Produced Within Joints In Rheumatoid Arthritis. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2009/01/090112212449.htm
Public Library of Science. "Antibodies Produced Within Joints In Rheumatoid Arthritis." ScienceDaily. www.sciencedaily.com/releases/2009/01/090112212449.htm (accessed September 15, 2014).

Share This



More Health & Medicine News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Contagious Respiratory Illness Continues to Spread Across U.S.

Contagious Respiratory Illness Continues to Spread Across U.S.

Reuters - US Online Video (Sep. 12, 2014) Hundreds of children in several states have been stricken by a serious respiratory illness that is spreading across the U.S. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Batters Sierra Leone Economy Too

Ebola Batters Sierra Leone Economy Too

Reuters - Business Video Online (Sep. 12, 2014) The World Health Organisation warns that local health workers in West Africa can't keep up with Ebola - and among those countries hardest hit by the outbreak, the economic damage is coming into focus, too. As David Pollard reports, Sierra Leone admits that growth in one of the poorest economies in the region is taking a beating. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins