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Breastfeeding May Prevent Breast Cancer

Date:
January 22, 2009
Source:
American Journal of Pathology
Summary:
Scientists have found that extended lactation protects again mammary tumor development. Women who breastfeed for greater than two years have a significantly reduced risk of developing breast cancer later in life.

Dr. Michael Lisanti and colleagues at Thomas Jefferson University found that extended lactation protects again mammary tumor development.

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Women who breastfeed for greater than two years have a significantly reduced risk of developing breast cancer later in life. It has been difficult to determine the cause of this benefit, however, due to the lack of a suitable animal model of extended lactation.

In this study, Sotgia et al demonstrated that mice deficient in caveolin 3, which is expressed in some mammary cells, had a constitutive lactation phenotype. Notably, caveolin 3-deficient mice were also protected against mammary tumor formation and lung metastases. These mice, therefore, provide a model of constitutive lactation that may be used to study the prevention or treatment of human breast cancers.

Dr. Lisanti's group suggest that "a lactation-based therapeutic strategy would provide a more natural and non-toxic approach to the development of novel anti-cancer therapies. In this regard, targeted reduction of Cav-3 levels in the mammary gland may represent a new therapeutic strategy for preventing the onset of human breast cancers."


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The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sotgia F, Casimiro MC, Bonuccelli G, Liu M, Menezes DW, Er O, Daumer KM, Mercier I, Witkiewicz AK, Minetti C, Capozza F, Gormley M, Quong AA, Rui H, Frank PG, Milliman JN, Knudsen ES, Zhou J, Wang C, Pestell RG, Lisanti MP. Loss of Caveolin-3 Induces a Lactogenic Microenvironment that is Protective Against Mammary Tumor Formation. Am J Pathol, 2009, 174: 613-629

Cite This Page:

American Journal of Pathology. "Breastfeeding May Prevent Breast Cancer." ScienceDaily. ScienceDaily, 22 January 2009. <www.sciencedaily.com/releases/2009/01/090122080721.htm>.
American Journal of Pathology. (2009, January 22). Breastfeeding May Prevent Breast Cancer. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2009/01/090122080721.htm
American Journal of Pathology. "Breastfeeding May Prevent Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/01/090122080721.htm (accessed March 31, 2015).

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