Featured Research

from universities, journals, and other organizations

Protein Encourages Cell Growth And Migration In Prostate Cancer

Date:
March 6, 2009
Source:
Thomas Jefferson University
Summary:
Researchers have identified a protein, proepithelin, that appears to play a significant role in the growth and migration of prostate cancer cells, especially androgen-independent prostate cancer cells.

Researchers from Thomas Jefferson University have identified a protein that appears to play a significant role in the growth and migration of prostate cancer cells, especially androgen-independent prostate cancer cells. The study was published in the American Journal of Pathology.

They also found that prostate cancer cells express more of the protein when compared to normal prostate cells, according to Andrea Morrione, Ph.D., an associate professor and director of Urology Research for the Kimmel Cancer Center at Jefferson.

Dr. Morrione conducted the study with Leonard Gomella, M.D., chairman of the department of Urology, Raffaele Baffa, M.D., an associate professor in the department of Urology, and Renato V. Iozzo, M.D., Ph.D., professor in the department of Pathology, Anatomy and Cell Biology.

Proepithelin is a growth factor that promotes cell cycle progression and cell growth in many cellular systems. According to Dr. Morrione, the overexpression of proepithelin by prostate cancer cells may prove to be a useful clinical marker to diagnose prostate cancer.

The presence of proepithelin also encourages cell migration, which is necessary for tumor metastasis. Thus, it may serve as a marker for metastasis.

Proepithelin has previously been shown to play a role in the formation of bladder cancer, and its overexpression is related to an aggressive form of breast cancer according to Dr. Morrione. It also has been shown to play a role in many other cancers, including glioblastomas, multiple myeloma, renal cell carcinoma, gastric cancer and ovarian cancer.

"There are two possible implications of our findings," Dr. Morrione said. "First, proepithelin could be a therapeutic target since it is overexpressed in prostate cancers.

Second, the overexpression of proepithelin could serve as a biomarker and be a diagnostic tool for prostate cancer."

Although localized prostate cancers are potentially curable by surgery and/or radiation therapy, there is no uniform effective treatment for hormone-refractory prostate cancer. There are no reliable prognostic markers to identify which of patients are likely to progress to metastatic disease.

Results of this study will also be presented at the 2009 ASCO Genitourinary Cancers Symposium.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Protein Encourages Cell Growth And Migration In Prostate Cancer." ScienceDaily. ScienceDaily, 6 March 2009. <www.sciencedaily.com/releases/2009/02/090226110659.htm>.
Thomas Jefferson University. (2009, March 6). Protein Encourages Cell Growth And Migration In Prostate Cancer. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/02/090226110659.htm
Thomas Jefferson University. "Protein Encourages Cell Growth And Migration In Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/02/090226110659.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins