Featured Research

from universities, journals, and other organizations

Having Parents With Bipolar Disorder Associated With Increased Risk Of Psychiatric Disorders

Date:
March 3, 2009
Source:
JAMA and Archives Journals
Summary:
Children and teens of parents with bipolar disorder appear to have an increased risk of early-onset bipolar disorder, mood disorders and anxiety disorders, according to a new report.

Children and teens of parents with bipolar disorder appear to have an increased risk of early-onset bipolar disorder, mood disorders and anxiety disorders, according to a report in the March issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

As many as 60 percent of patients with bipolar disorder experience symptoms before age 21, according to background information in the article. Identifying the condition early may improve long-term outcomes, potentially preventing high psychosocial and medical costs. Having family members with bipolar disorder is the best predictor of whether an individual will go on to develop the condition, the authors note. "Therefore, carefully evaluating and prospectively following the psychopathology of offspring of parents with bipolar disorder and comparing them with offspring of parents with and without non-bipolar disorder psychopathology, are critical for identifying the early clinical presentation of bipolar disorder," they write.

Boris Birmaher, M.D., of Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, and colleagues compared 388 offspring (ages 6 to 18) of 233 parents with bipolar disorder to 251 offspring of 143 demographically matched control parents. Parents were assessed for psychiatric disorders, family psychiatric history, family environment and other variables, and were also interviewed about their children. Children were assessed directly for bipolar disorder and other psychiatric disorders by researchers who did not know their parents' diagnoses.

Compared with the offspring of control parents, children of parents with bipolar disorder had an increased risk of having a bipolar spectrum disorder (41 or 10.6 percent vs. two or 0.8 percent) and having any mood or anxiety disorder. Children in families where both parents had bipolar disorders also were more likely than those in families containing one parent with bipolar disorder to develop the condition (four of 14 or 28.6 percent vs. 37 of 374 or 9.9 percent); however, their risk for other psychiatric disorders was the same as offspring of one parent with bipolar disorder.

"Consistent with the literature, most parents with bipolar disorder recollected that their illness started before age 20 years and about 20 percent had illness that started before age 13 years," the authors write. "In contrast, most of their children developed their first bipolar disorder episode before age 12 years, suggesting the possibility that parents were more perceptive of their children's symptoms early in life or perhaps that bipolar disorder has more penetrance and manifests earlier in new generations."

The findings have important clinical implications, they note. "Clinicians who treat adults with bipolar disorder should question those who are parents about their children's psychopathology to offer prompt identification and early interventions for any psychiatric problems that may be affecting the children's functioning, particularly early-onset bipolar disorder," they continue. Further studies are needed to help determine the clinical, biological and genetic risk factors that may be modified to prevent the development of psychiatric disorders in the offspring of those with bipolar disorder.

This work was supported by a grant from the National Institute of Mental Health. Dr. Birmaher has participated in forums sponsored by some pharmaceutical companies (Solvay, Abcomm Inc. and Jazz Pharmaceuticals Inc.). Co-author Dr. Kupfer has served on the advisory boards of Pfizer Inc., Eli Lilly and Co., Forest Pharmaceuticals Inc., F. Hoffman–La Roche Ltd. and Solvay/Wyeth Pharmaceuticals and has been a consultant to Servier Amιrique.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Birmaher et al. Lifetime Psychiatric Disorders in School-aged Offspring of Parents With Bipolar Disorder: The Pittsburgh Bipolar Offspring Study. Archives of General Psychiatry, 2009; 66 (3): 287 DOI: 10.1001/archgenpsychiatry.2008.546

Cite This Page:

JAMA and Archives Journals. "Having Parents With Bipolar Disorder Associated With Increased Risk Of Psychiatric Disorders." ScienceDaily. ScienceDaily, 3 March 2009. <www.sciencedaily.com/releases/2009/03/090302183118.htm>.
JAMA and Archives Journals. (2009, March 3). Having Parents With Bipolar Disorder Associated With Increased Risk Of Psychiatric Disorders. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2009/03/090302183118.htm
JAMA and Archives Journals. "Having Parents With Bipolar Disorder Associated With Increased Risk Of Psychiatric Disorders." ScienceDaily. www.sciencedaily.com/releases/2009/03/090302183118.htm (accessed October 23, 2014).

Share This



More Mind & Brain News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Academic Scandal Shocks UNC

Academic Scandal Shocks UNC

AP (Oct. 23, 2014) — A scandal involving bogus classes and inflated grades at the University of North Carolina was bigger than previously reported, a new investigation found. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Working Mother Getaway: Beaches Turks & Caicos

Working Mother Getaway: Beaches Turks & Caicos

Working Mother (Oct. 22, 2014) — Feast your eyes on this gorgeous family-friendly resort. Video provided by Working Mother
Powered by NewsLook.com
What Your Favorite Color Says About You

What Your Favorite Color Says About You

Buzz60 (Oct. 22, 2014) — We all have one color we love to wear, and believe it or not, your color preference may reveal some of your character traits. In celebration of National Color Day, Krystin Goodwin (@kyrstingoodwin) highlights what your favorite colors may say about you. Video provided by Buzz60
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins