Featured Research

from universities, journals, and other organizations

Defibrillators May Have Little Benefit For Older People With Comorbidities

Date:
March 16, 2009
Source:
Canadian Medical Association Journal
Summary:
Older people with comorbidities and those with multiple hospital admissions related to heart failure are unlikely to receive a meaningful survival benefit from implanted defibrillators, found a new study.

Older people with comorbidities and those with multiple hospital admissions related to heart failure are unlikely to receive a meaningful survival benefit from implanted defibrillators, found a study in the Canadian Medical Association Journal by researchers from Brigham and Women's Hospital and Harvard Medical School in Boston, Massachusetts.

The cohort study looked at more than 14 000 patients with heart failure using an administrative database over 5 years. The mean age of the group was 77 years, and patients had a high level of comorbidities such as other cardiovascular disease, diabetes, chronic pulmonary disease and kidney disease.

Survival declined progressively after repeated hospital admissions and implantable defibrillators would have apparently extended life by just over 6 months. However, patients under 65 years of age and older patients without kidney disease, cancer or dementia would be most likely to benefit from implantable defibrillators to prevent sudden death.

"In contrast to our observations, information from the US National Cardiovascular Data Registry for 2006-2007 indicates that implantable defibrillators are frequently implanted in older patients with heart failure: 61% of patients were 65 years or older, and 15% were 80 years or older," write Dr. Soko Setoguchi and coauthors. Fifty-eight percent of patients had previously been admitted to hospital and comorbidities were common.

The health and social burden of heart failure is significant, with 1.09 million related hospital admissions in the United States in 2003 and 106 130 admissions in Canada in 2001. Implantable defibrillators have shown benefit for people with heart failure in studies, but trials often exclude the elderly and patients with comorbidities.

"As Setoguchi and colleagues point out, patients at extremely high risk of death, including patients with prior (particularly multiple) heart failure hospitalizations and chronic kidney disease, have such a high risk of all-cause non-arrhythmic death that even if the 20% or so of potentially treatable sudden deaths were prevented, the overall risk of death would remain prohibitively high," writes Dr. Paul Dorian from the University of Toronto and St. Michael's Hospital, Toronto, in a related commentary.


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Cite This Page:

Canadian Medical Association Journal. "Defibrillators May Have Little Benefit For Older People With Comorbidities." ScienceDaily. ScienceDaily, 16 March 2009. <www.sciencedaily.com/releases/2009/03/090316173204.htm>.
Canadian Medical Association Journal. (2009, March 16). Defibrillators May Have Little Benefit For Older People With Comorbidities. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/03/090316173204.htm
Canadian Medical Association Journal. "Defibrillators May Have Little Benefit For Older People With Comorbidities." ScienceDaily. www.sciencedaily.com/releases/2009/03/090316173204.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins