Featured Research

from universities, journals, and other organizations

New Theoretical Model Of Tumor Growth And Metastasis Based On Differences In Tissue Pressure

Date:
March 25, 2009
Source:
HFSP Publishing
Summary:
A new article describes a theoretical model of tumor growth and metastasis based on differences in tissue pressure.

The progression of cancer is a multi-step process. Over 80% of malignant tumors are carcinomas that originate in epithelial tissues from where they invade the connective tissue. At some point, subpopulations of cells may detach from the primary tumor and spread via the bloodstream and the lymphatic system. Some of them give rise to metastases in distant organs.

The metastatic cascade is a very inefficient process, as only one in about a thousand cells that leave the primary tumor goes on to form a macroscopic secondary tumor. The main contribution to metastatic inefficiency arises from the failure of cancerous cells to grow inside invaded organs. Metastatic tumors also show preferential growth in different organs. Hence, the efficiency of the metastatic process depends on specific interactions between the invading cancer cells and the local organ tissues.

In an Article published on the HFSP Journal website, Risler, Prost and Joanny from Institut Curie in Paris suggest that this is due to a difference of pressure between tumor cells and the host tissue. Combining the laws of mechanics and the biological state of homeostasis, the authors propose that every biological tissue regulates to a preferred pressure called homeostatic pressure, and that an increased homeostatic pressure is a generic trait of neoplastic tissues. This property can drive tumour growth at the expense of the host tissue. Metastases account for the majority of patients' deaths due to cancer, and thus understanding the metastatic process is of critical importance.


Story Source:

The above story is based on materials provided by HFSP Publishing. Note: Materials may be edited for content and length.


Journal Reference:

  1. Basan et al. Homeostatic competition drives tumor growth and metastasis nucleation. Advanced Online Publication Articles for HFSP Journal, 2009; 1 (1): 98 DOI: 10.2976/1.3086732

Cite This Page:

HFSP Publishing. "New Theoretical Model Of Tumor Growth And Metastasis Based On Differences In Tissue Pressure." ScienceDaily. ScienceDaily, 25 March 2009. <www.sciencedaily.com/releases/2009/03/090323143902.htm>.
HFSP Publishing. (2009, March 25). New Theoretical Model Of Tumor Growth And Metastasis Based On Differences In Tissue Pressure. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2009/03/090323143902.htm
HFSP Publishing. "New Theoretical Model Of Tumor Growth And Metastasis Based On Differences In Tissue Pressure." ScienceDaily. www.sciencedaily.com/releases/2009/03/090323143902.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins