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Tracking Acute Kidney Injury

Date:
April 3, 2009
Source:
American Journal of Pathology
Summary:
Researchers in Japan have identified a novel biomarker to monitor acute kidney injury.

Dr. Eisei Noiri and colleagues at the University of Tokyo, Japan identified a novel biomarker to monitor acute kidney injury.

They present their data in the April 2009 issue of The American Journal of Pathology.

Acute kidney injury may be reversible if treated promptly and appropriately. Novel biomarkers therefore need to be developed to identify injury at early time points as well as to estimate the severity of the damage.

Negishi et al examined whether levels of urinary L-type fatty acid-binding protein (L-FABP), a protein found in the kidney that is secreted in the urine upon kidney injury, could be used to monitor acute kidney injury. Levels of L-FABP correlated with the level of acute kidney injury at significantly earlier time points than levels of conventional renal markers such as blood urea nitrogen (BUN) or urinary N-acetyl-D-glucosaminidase (NAG). In addition, L-FABP showed better correlation than BUN or NAG with final histological injury scores, especially at early time points.

L-FABP thus represents a better choice than conventional renal markers for evaluating early acute kidney injury. Future studies will "evaluat[e] various human AKI populations … to confirm the significance of urinary L-FABP as a forecasting biomarker of pathological and functional damage."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Negishi K, Noiri E, Doi K, Maeda R, Sugaya T, Portilla D, Fujita T. Monitoring of Urinary L-Type Fatty Acid-Binding Protein Predicts Histological Severity of Acute Kidney Injury. American Journal Of Pathology, 2009; DOI: 10.2353/ajpath.2009.080644

Cite This Page:

American Journal of Pathology. "Tracking Acute Kidney Injury." ScienceDaily. ScienceDaily, 3 April 2009. <www.sciencedaily.com/releases/2009/03/090325114439.htm>.
American Journal of Pathology. (2009, April 3). Tracking Acute Kidney Injury. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2009/03/090325114439.htm
American Journal of Pathology. "Tracking Acute Kidney Injury." ScienceDaily. www.sciencedaily.com/releases/2009/03/090325114439.htm (accessed April 17, 2014).

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